The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
Abstract Background Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various c...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Clinical Epigenetics |
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| Online Access: | https://doi.org/10.1186/s13148-023-01426-8 |
| _version_ | 1811175850930864128 |
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| author | Xiaonan Wang Wancui Zhu Qian Long Enni Chen Haohui Sun Xiaodi Li Hailin Xu Weizhao Li Pei Dong Liru He Miao Chen Wuguo Deng |
| author_facet | Xiaonan Wang Wancui Zhu Qian Long Enni Chen Haohui Sun Xiaodi Li Hailin Xu Weizhao Li Pei Dong Liru He Miao Chen Wuguo Deng |
| author_sort | Xiaonan Wang |
| collection | DOAJ |
| description | Abstract Background Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. Results We found that IL18 was significantly over-expressed in RCC tumor tissues compared to normal adjacent tissues The IL18 promoter region was hypomethylated, which was strongly correlated with elevated IL18 mRNA expression, and predicted advanced clinicopathological characteristics and shorter overall survival. Furthermore, we found that IL18 promoter methylation was significantly related to the down-regulation of immune checkpoint molecules and increase of CD8 + T cell infiltration in RCC tumor tissues. Conclusions We have identified the important role of IL18 promoter methylation and expression, which are associated with clinicopathological characteristics, overall survival, immune cell infiltration and expression of immune checkpoint molecules in RCC. We present the rationale for IL18 promoter methylation as a molecular biomarker for predicting the response of RCC to immune checkpoint inhibitors. |
| first_indexed | 2024-04-10T19:42:36Z |
| format | Article |
| id | doaj.art-f9a2103dc49446a497e96375417f6156 |
| institution | Directory Open Access Journal |
| issn | 1868-7083 |
| language | English |
| last_indexed | 2024-04-10T19:42:36Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-f9a2103dc49446a497e96375417f61562023-01-29T12:15:23ZengBMCClinical Epigenetics1868-70832023-01-0115111610.1186/s13148-023-01426-8The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinomaXiaonan Wang0Wancui Zhu1Qian Long2Enni Chen3Haohui Sun4Xiaodi Li5Hailin Xu6Weizhao Li7Pei Dong8Liru He9Miao Chen10Wuguo Deng11Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineDepartment of General Surgery, The Second Xiangya Hospital, Central South UniversitySun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineThe First Affiliated Hospital, Sun Yat-Sen UniversityThe Seventh Affiliated Hospital, Sun Yat-Sen UniversitySun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineAbstract Background Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. Results We found that IL18 was significantly over-expressed in RCC tumor tissues compared to normal adjacent tissues The IL18 promoter region was hypomethylated, which was strongly correlated with elevated IL18 mRNA expression, and predicted advanced clinicopathological characteristics and shorter overall survival. Furthermore, we found that IL18 promoter methylation was significantly related to the down-regulation of immune checkpoint molecules and increase of CD8 + T cell infiltration in RCC tumor tissues. Conclusions We have identified the important role of IL18 promoter methylation and expression, which are associated with clinicopathological characteristics, overall survival, immune cell infiltration and expression of immune checkpoint molecules in RCC. We present the rationale for IL18 promoter methylation as a molecular biomarker for predicting the response of RCC to immune checkpoint inhibitors.https://doi.org/10.1186/s13148-023-01426-8Renal cell carcinoma (RCC)IL18DNA methylationEpigenetic biomarkerTumor immune cell infiltration |
| spellingShingle | Xiaonan Wang Wancui Zhu Qian Long Enni Chen Haohui Sun Xiaodi Li Hailin Xu Weizhao Li Pei Dong Liru He Miao Chen Wuguo Deng The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma Clinical Epigenetics Renal cell carcinoma (RCC) IL18 DNA methylation Epigenetic biomarker Tumor immune cell infiltration |
| title | The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma |
| title_full | The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma |
| title_fullStr | The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma |
| title_full_unstemmed | The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma |
| title_short | The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma |
| title_sort | prognostic value and immune correlation of il18 expression and promoter methylation in renal cell carcinoma |
| topic | Renal cell carcinoma (RCC) IL18 DNA methylation Epigenetic biomarker Tumor immune cell infiltration |
| url | https://doi.org/10.1186/s13148-023-01426-8 |
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