Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection followed by adjuvant and systemic chemotherapy are the most meticulously followed treatment procedures but the complex etiology and hig...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-018-0538-7 |
| _version_ | 1818335258059210752 |
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| author | K. Lohitesh Rajdeep Chowdhury Sudeshna Mukherjee |
| author_facet | K. Lohitesh Rajdeep Chowdhury Sudeshna Mukherjee |
| author_sort | K. Lohitesh |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection followed by adjuvant and systemic chemotherapy are the most meticulously followed treatment procedures but the complex etiology and high metastatic potential of the disease renders surgical treatment futile in majority of the cases. Another hindrance to the scenario is the acquired resistance to drugs resulting in relapse of the disease. Hence, to provide insights into development of novel therapeutic targets and diagnostic biomarkers, this review focuses on the various molecular mechanisms underlying chemoresistance in HCC. We have provided a comprehensive summary of the various strategies adopted by HCC cells, extending from apoptosis evasion, autophagy activation, drug expulsion to epigenetic transformation as modes of therapy resistance. The role of stem cells in imparting chemoresistance is also discussed. Furthermore, the review also focuses on how this knowledge might be exploited for the development of an effective, prospective therapy against HCC. |
| first_indexed | 2024-12-13T14:20:34Z |
| format | Article |
| id | doaj.art-f9a37a76d7e2419cb1b64f34b3d1a34b |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-13T14:20:34Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-f9a37a76d7e2419cb1b64f34b3d1a34b2022-12-21T23:42:06ZengBMCCancer Cell International1475-28672018-03-0118111510.1186/s12935-018-0538-7Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insightK. Lohitesh0Rajdeep Chowdhury1Sudeshna Mukherjee2Department of Biological-Sciences, Birla Institute of Technology and Sciences (BITS)Department of Biological-Sciences, Birla Institute of Technology and Sciences (BITS)Department of Biological-Sciences, Birla Institute of Technology and Sciences (BITS)Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection followed by adjuvant and systemic chemotherapy are the most meticulously followed treatment procedures but the complex etiology and high metastatic potential of the disease renders surgical treatment futile in majority of the cases. Another hindrance to the scenario is the acquired resistance to drugs resulting in relapse of the disease. Hence, to provide insights into development of novel therapeutic targets and diagnostic biomarkers, this review focuses on the various molecular mechanisms underlying chemoresistance in HCC. We have provided a comprehensive summary of the various strategies adopted by HCC cells, extending from apoptosis evasion, autophagy activation, drug expulsion to epigenetic transformation as modes of therapy resistance. The role of stem cells in imparting chemoresistance is also discussed. Furthermore, the review also focuses on how this knowledge might be exploited for the development of an effective, prospective therapy against HCC.http://link.springer.com/article/10.1186/s12935-018-0538-7CancerHCCChemoresistanceMetastasisApoptosisAutophagy |
| spellingShingle | K. Lohitesh Rajdeep Chowdhury Sudeshna Mukherjee Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight Cancer Cell International Cancer HCC Chemoresistance Metastasis Apoptosis Autophagy |
| title | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight |
| title_full | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight |
| title_fullStr | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight |
| title_full_unstemmed | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight |
| title_short | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight |
| title_sort | resistance a major hindrance to chemotherapy in hepatocellular carcinoma an insight |
| topic | Cancer HCC Chemoresistance Metastasis Apoptosis Autophagy |
| url | http://link.springer.com/article/10.1186/s12935-018-0538-7 |
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