Liver injury and glatiramer acetate, an uncommon association: case report and literature review
We report the case of a 65-year-old woman who presented with a 1-month history of progressive paraparesia associated with a thoracic lesion with irregular ring-like gadolinium enhancement. Biopsy of the lesion confirmed the demyelinating origin and brain magnetic resonance imaging showed additional...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-11-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/1756285617722352 |
| _version_ | 1818491937090437120 |
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| author | Javier Almeida Nuria Solà-Valls Elisa Pose Yolanda Blanco María Sepúlveda Sara Llufriu Pere Gines Albert Saiz |
| author_facet | Javier Almeida Nuria Solà-Valls Elisa Pose Yolanda Blanco María Sepúlveda Sara Llufriu Pere Gines Albert Saiz |
| author_sort | Javier Almeida |
| collection | DOAJ |
| description | We report the case of a 65-year-old woman who presented with a 1-month history of progressive paraparesia associated with a thoracic lesion with irregular ring-like gadolinium enhancement. Biopsy of the lesion confirmed the demyelinating origin and brain magnetic resonance imaging showed additional lesions demonstrative of dissemination in space. Immunomodulatory therapy with glatiramer acetate (GA) was started after having a second relapse 2 months later. Shortly after initiation, the patient developed acute hepatitis. Liver function tests returned to normal values 5 months after discontinuation and the patient was diagnosed with drug-induced liver injury (DILI) associated with GA. A literature review identified 11 previous cases of GA-related liver injury associated with two specific mechanisms: DILI (seven cases) and autoimmune hepatitis (four cases). Despite the fact that GA hepatic toxicity is uncommon and laboratory monitoring is not required during GA therapy, it should be considered at least in some special conditions such as comorbidities and previous history of DILI associated with other drugs. |
| first_indexed | 2024-12-10T17:37:06Z |
| format | Article |
| id | doaj.art-f9a3d441144648aab8627b26c4cc0143 |
| institution | Directory Open Access Journal |
| issn | 1756-2864 |
| language | English |
| last_indexed | 2024-12-10T17:37:06Z |
| publishDate | 2017-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-f9a3d441144648aab8627b26c4cc01432022-12-22T01:39:29ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642017-11-011010.1177/1756285617722352Liver injury and glatiramer acetate, an uncommon association: case report and literature reviewJavier AlmeidaNuria Solà-VallsElisa PoseYolanda BlancoMaría SepúlvedaSara LlufriuPere GinesAlbert SaizWe report the case of a 65-year-old woman who presented with a 1-month history of progressive paraparesia associated with a thoracic lesion with irregular ring-like gadolinium enhancement. Biopsy of the lesion confirmed the demyelinating origin and brain magnetic resonance imaging showed additional lesions demonstrative of dissemination in space. Immunomodulatory therapy with glatiramer acetate (GA) was started after having a second relapse 2 months later. Shortly after initiation, the patient developed acute hepatitis. Liver function tests returned to normal values 5 months after discontinuation and the patient was diagnosed with drug-induced liver injury (DILI) associated with GA. A literature review identified 11 previous cases of GA-related liver injury associated with two specific mechanisms: DILI (seven cases) and autoimmune hepatitis (four cases). Despite the fact that GA hepatic toxicity is uncommon and laboratory monitoring is not required during GA therapy, it should be considered at least in some special conditions such as comorbidities and previous history of DILI associated with other drugs.https://doi.org/10.1177/1756285617722352 |
| spellingShingle | Javier Almeida Nuria Solà-Valls Elisa Pose Yolanda Blanco María Sepúlveda Sara Llufriu Pere Gines Albert Saiz Liver injury and glatiramer acetate, an uncommon association: case report and literature review Therapeutic Advances in Neurological Disorders |
| title | Liver injury and glatiramer acetate, an uncommon association: case report and
literature review |
| title_full | Liver injury and glatiramer acetate, an uncommon association: case report and
literature review |
| title_fullStr | Liver injury and glatiramer acetate, an uncommon association: case report and
literature review |
| title_full_unstemmed | Liver injury and glatiramer acetate, an uncommon association: case report and
literature review |
| title_short | Liver injury and glatiramer acetate, an uncommon association: case report and
literature review |
| title_sort | liver injury and glatiramer acetate an uncommon association case report and literature review |
| url | https://doi.org/10.1177/1756285617722352 |
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