HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals

HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals

The HIV-1 envelope glycoprotein (Env) is synthesized in the endoplasmic reticulum as a trimeric gp160 precursor, which requires proteolytic cleavage by a cellular furin protease to mediate virus-cell fusion. Env is conformationally flexible but controls its transition from the unbound “closed” confo...

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Bibliographic Details
Main Authors: Jérémie Prévost, Halima Medjahed, Dani Vézina, Hung-Ching Chen, Beatrice H. Hahn, Amos B. Smith, Andrés Finzi
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Viruses
Subjects:
HIV-1
Env glycoprotein
furin cleavage site
CD4 mimetics
Temsavir
nnAbs
Online Access:https://www.mdpi.com/1999-4915/13/11/2236

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