When is Sirt1 activity bad for dying neurons?
Sirt1, the class III histone deacetylase, is generally associated with increased life span and with a pro-survival effect in neurons stressed by pathological factors. Recent work, however, suggests that Sirt1 silencing could also promote neuronal survival. A possible reason suggested is Sirt1 silenc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00186/full |
| _version_ | 1818930502500876288 |
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| author | Bor Luen eTang Fanny eNg |
| author_facet | Bor Luen eTang Fanny eNg |
| author_sort | Bor Luen eTang |
| collection | DOAJ |
| description | Sirt1, the class III histone deacetylase, is generally associated with increased life span and with a pro-survival effect in neurons stressed by pathological factors. Recent work, however, suggests that Sirt1 silencing could also promote neuronal survival. A possible reason suggested is Sirt1 silencing enhanced expression of both IGF-1 and IGF-1 receptor (IGF-1R), signaling from which promotes survival. This work adds to the small but steady stream of findings that are diametrically opposite to the overwhelmingly large amount of evidence supporting a beneficial effect of sustaining or enhancing Sirt1 activity in neuronal injuries and diseases. We attempt to reconcile this discrepancy below by noting evidence that elevated Sirt1 levels and/or activity may not help, and could even adversely exacerbates demise, during events of acute neuronal damage or death. However, sustained Sirt1 activation would be beneficial in situations of chronic and long-term sub-lethal stresses, and the status of IGF-1 signaling may influence Sirt1 action in a context dependent manner. |
| first_indexed | 2024-12-20T04:01:43Z |
| format | Article |
| id | doaj.art-f9a81935061f464391c4b8711eecd1c0 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-20T04:01:43Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-f9a81935061f464391c4b8711eecd1c02022-12-21T19:54:09ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-10-01710.3389/fncel.2013.0018667329When is Sirt1 activity bad for dying neurons?Bor Luen eTang0Fanny eNg1National University of SingaporeNational University of SingaporeSirt1, the class III histone deacetylase, is generally associated with increased life span and with a pro-survival effect in neurons stressed by pathological factors. Recent work, however, suggests that Sirt1 silencing could also promote neuronal survival. A possible reason suggested is Sirt1 silencing enhanced expression of both IGF-1 and IGF-1 receptor (IGF-1R), signaling from which promotes survival. This work adds to the small but steady stream of findings that are diametrically opposite to the overwhelmingly large amount of evidence supporting a beneficial effect of sustaining or enhancing Sirt1 activity in neuronal injuries and diseases. We attempt to reconcile this discrepancy below by noting evidence that elevated Sirt1 levels and/or activity may not help, and could even adversely exacerbates demise, during events of acute neuronal damage or death. However, sustained Sirt1 activation would be beneficial in situations of chronic and long-term sub-lethal stresses, and the status of IGF-1 signaling may influence Sirt1 action in a context dependent manner.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00186/fullNADNeuroprotectionSIRT1IGF-Ineuronal survival |
| spellingShingle | Bor Luen eTang Fanny eNg When is Sirt1 activity bad for dying neurons? Frontiers in Cellular Neuroscience NAD Neuroprotection SIRT1 IGF-I neuronal survival |
| title | When is Sirt1 activity bad for dying neurons? |
| title_full | When is Sirt1 activity bad for dying neurons? |
| title_fullStr | When is Sirt1 activity bad for dying neurons? |
| title_full_unstemmed | When is Sirt1 activity bad for dying neurons? |
| title_short | When is Sirt1 activity bad for dying neurons? |
| title_sort | when is sirt1 activity bad for dying neurons |
| topic | NAD Neuroprotection SIRT1 IGF-I neuronal survival |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00186/full |
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