Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering
Additive manufacturing (AM) is an increasingly important technology for fabricating complex and customized structures using a range of advanced materials and is now playing a critical role in the field of bone tissue engineering (BTE). Two-dimensional nanomaterials (2D NMs) have demonstrated their s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523007773 |
| _version_ | 1797647929937231872 |
|---|---|
| author | Na Li Junkui Cui Minghan Chi Florian M. Thieringer Neha Sharma |
| author_facet | Na Li Junkui Cui Minghan Chi Florian M. Thieringer Neha Sharma |
| author_sort | Na Li |
| collection | DOAJ |
| description | Additive manufacturing (AM) is an increasingly important technology for fabricating complex and customized structures using a range of advanced materials and is now playing a critical role in the field of bone tissue engineering (BTE). Two-dimensional nanomaterials (2D NMs) have demonstrated their significance in biomedical science. The convergence of 2D NMs to 3D printing (3DP) technology to create the desired bone scaffolds has become an alternative approach to breakthrough bottlenecks of remaining challenges in BTE, which can potentially achieve the multifunctionality of a bone substitute. The first part of this review provides an overview of the mechanism and critical comparison of the commonly-used 3DP and bioprinting methods. Each method's strengths and weaknesses are evaluated to provide a comprehensive understanding of the current state and for future development. Next, the general synthetic approach to produce 2D NMs, including the top-down and bottom-up approaches, is summarized. Furthermore, an in-depth coverage of the recent advances in combining various 2D NMs with specific 3D printing techniques for bone regeneration is covered. By examining the latest research in this field, this study aims to shed light on the potential of 2D NMs and 3DP technology to revolutionize the field of bone regeneration. |
| first_indexed | 2024-03-11T15:24:46Z |
| format | Article |
| id | doaj.art-f9a965cea973450ea4ad3657017da862 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T15:24:46Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-f9a965cea973450ea4ad3657017da8622023-10-28T05:06:38ZengElsevierMaterials & Design0264-12752023-10-01234112362Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineeringNa Li0Junkui Cui1Minghan Chi2Florian M. Thieringer3Neha Sharma4Medical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Earth and Environmental Studies, Montclair State University, Montclair, NJ, United StatesMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland; Corresponding author at: Hegenheimermattweg 167b, 4123 Allschwil, Switerland.Medical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland; Oral and Cranio-Maxillofacial Surgery, University of Basel, Basel, SwitzerlandMedical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland; Oral and Cranio-Maxillofacial Surgery, University of Basel, Basel, SwitzerlandAdditive manufacturing (AM) is an increasingly important technology for fabricating complex and customized structures using a range of advanced materials and is now playing a critical role in the field of bone tissue engineering (BTE). Two-dimensional nanomaterials (2D NMs) have demonstrated their significance in biomedical science. The convergence of 2D NMs to 3D printing (3DP) technology to create the desired bone scaffolds has become an alternative approach to breakthrough bottlenecks of remaining challenges in BTE, which can potentially achieve the multifunctionality of a bone substitute. The first part of this review provides an overview of the mechanism and critical comparison of the commonly-used 3DP and bioprinting methods. Each method's strengths and weaknesses are evaluated to provide a comprehensive understanding of the current state and for future development. Next, the general synthetic approach to produce 2D NMs, including the top-down and bottom-up approaches, is summarized. Furthermore, an in-depth coverage of the recent advances in combining various 2D NMs with specific 3D printing techniques for bone regeneration is covered. By examining the latest research in this field, this study aims to shed light on the potential of 2D NMs and 3DP technology to revolutionize the field of bone regeneration.http://www.sciencedirect.com/science/article/pii/S0264127523007773Two-dimensionalNanomaterials3DPAdditive manufacturingBoneScaffold |
| spellingShingle | Na Li Junkui Cui Minghan Chi Florian M. Thieringer Neha Sharma Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering Materials & Design Two-dimensional Nanomaterials 3DP Additive manufacturing Bone Scaffold |
| title | Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering |
| title_full | Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering |
| title_fullStr | Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering |
| title_full_unstemmed | Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering |
| title_short | Building a better bone: The synergy of 2D nanomaterials and 3D printing for bone tissue engineering |
| title_sort | building a better bone the synergy of 2d nanomaterials and 3d printing for bone tissue engineering |
| topic | Two-dimensional Nanomaterials 3DP Additive manufacturing Bone Scaffold |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523007773 |
| work_keys_str_mv | AT nali buildingabetterbonethesynergyof2dnanomaterialsand3dprintingforbonetissueengineering AT junkuicui buildingabetterbonethesynergyof2dnanomaterialsand3dprintingforbonetissueengineering AT minghanchi buildingabetterbonethesynergyof2dnanomaterialsand3dprintingforbonetissueengineering AT florianmthieringer buildingabetterbonethesynergyof2dnanomaterialsand3dprintingforbonetissueengineering AT nehasharma buildingabetterbonethesynergyof2dnanomaterialsand3dprintingforbonetissueengineering |