Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i>

Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6<i>Z</i>)-neomanoalide-24-acetate, two diastereomers of 24-<i>O</i>-methylmanoalide, luffarioli...

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Bibliographic Details
Main Authors: Wirongrong Kaweetripob, Chulabhorn Mahidol, Pittaya Tuntiwachwuttikul, Somsak Ruchirawat, Hunsa Prawat
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/16/12/474
Description
Summary:Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6<i>Z</i>)-neomanoalide-24-acetate, two diastereomers of 24-<i>O</i>-methylmanoalide, luffariolide B, manoalide, (6<i>E</i>)- and (6<i>Z</i>)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-<i>O</i>-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-<i>O</i>-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1<i>H</i>-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge <i>Hyrtios erectus</i>. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher&#8217;s method. The cytotoxic activities for the isolated compounds have been reported.
ISSN:1660-3397