Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i>
Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6<i>Z</i>)-neomanoalide-24-acetate, two diastereomers of 24-<i>O</i>-methylmanoalide, luffarioli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/16/12/474 |
| _version_ | 1798034153716842496 |
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| author | Wirongrong Kaweetripob Chulabhorn Mahidol Pittaya Tuntiwachwuttikul Somsak Ruchirawat Hunsa Prawat |
| author_facet | Wirongrong Kaweetripob Chulabhorn Mahidol Pittaya Tuntiwachwuttikul Somsak Ruchirawat Hunsa Prawat |
| author_sort | Wirongrong Kaweetripob |
| collection | DOAJ |
| description | Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6<i>Z</i>)-neomanoalide-24-acetate, two diastereomers of 24-<i>O</i>-methylmanoalide, luffariolide B, manoalide, (6<i>E</i>)- and (6<i>Z</i>)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-<i>O</i>-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-<i>O</i>-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1<i>H</i>-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge <i>Hyrtios erectus</i>. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher’s method. The cytotoxic activities for the isolated compounds have been reported. |
| first_indexed | 2024-04-11T20:40:17Z |
| format | Article |
| id | doaj.art-f9a975bfff8143f8962dad5c78f85341 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:40:17Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f9a975bfff8143f8962dad5c78f853412022-12-22T04:04:14ZengMDPI AGMarine Drugs1660-33972018-11-01161247410.3390/md16120474md16120474Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i>Wirongrong Kaweetripob0Chulabhorn Mahidol1Pittaya Tuntiwachwuttikul2Somsak Ruchirawat3Hunsa Prawat4Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, ThailandLaboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Phuket 83000, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, ThailandFour sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6<i>Z</i>)-neomanoalide-24-acetate, two diastereomers of 24-<i>O</i>-methylmanoalide, luffariolide B, manoalide, (6<i>E</i>)- and (6<i>Z</i>)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-<i>O</i>-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-<i>O</i>-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1<i>H</i>-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge <i>Hyrtios erectus</i>. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher’s method. The cytotoxic activities for the isolated compounds have been reported.https://www.mdpi.com/1660-3397/16/12/474<i>Hyrtios erectus</i> (CRI 572 and CRI 588)Thorectidaemanoalidesscalarane2-furanone derivativescytotoxic activities |
| spellingShingle | Wirongrong Kaweetripob Chulabhorn Mahidol Pittaya Tuntiwachwuttikul Somsak Ruchirawat Hunsa Prawat Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> Marine Drugs <i>Hyrtios erectus</i> (CRI 572 and CRI 588) Thorectidae manoalides scalarane 2-furanone derivatives cytotoxic activities |
| title | Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> |
| title_full | Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> |
| title_fullStr | Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> |
| title_full_unstemmed | Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> |
| title_short | Cytotoxic Sesterterpenes from Thai Marine Sponge <i>Hyrtios erectus</i> |
| title_sort | cytotoxic sesterterpenes from thai marine sponge i hyrtios erectus i |
| topic | <i>Hyrtios erectus</i> (CRI 572 and CRI 588) Thorectidae manoalides scalarane 2-furanone derivatives cytotoxic activities |
| url | https://www.mdpi.com/1660-3397/16/12/474 |
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