MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity
Obesity and osteoporosis are global health problems characterized by high rates of prevalence and mortality due to complications. As people with visceral obesity age, the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) increases, and adipocytes become the predominant stromal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-06-01
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| Series: | Frontiers in Bioscience-Scholar |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBS/14/3/10.31083/j.fbs1403017 |
| _version_ | 1811265774115880960 |
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| author | Maria Vulf Igor Khlusov Kristina Yurova Natalia Todosenko Alexandra Komar Ivan Kozlov Vladimir Malashchenko Daria Shunkina Olga Khaziakhmatova Larisa Litvinova |
| author_facet | Maria Vulf Igor Khlusov Kristina Yurova Natalia Todosenko Alexandra Komar Ivan Kozlov Vladimir Malashchenko Daria Shunkina Olga Khaziakhmatova Larisa Litvinova |
| author_sort | Maria Vulf |
| collection | DOAJ |
| description | Obesity and osteoporosis are global health problems characterized by high rates of prevalence and mortality due to complications. As people with visceral obesity age, the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) increases, and adipocytes become the predominant stromal cells in the bone marrow microenvironment, which hinders the physiological regeneration and mineralization of bone tissue. Primary and secondary osteoporosis remain severe progressive diseases. Both osteoporosis and obesity are associated with microRNAs (miRNAs) that induce adipogenesis and osteoresorption. This review presents analyses of the roles and clinical potential of miRNAs in the epigenetic control of BMSC differentiation and the formation and function of osteoclasts in osteoporosis with and without obesity. Understanding the fine-tuned regulation of the expression of genes critical for the balance of osteogenesis/osteolysis processes may provide hope for the development of effective and safe osteoporosis therapies in the future. |
| first_indexed | 2024-04-12T20:29:58Z |
| format | Article |
| id | doaj.art-f9a98e52d910489cb63feef6e3ce8cfd |
| institution | Directory Open Access Journal |
| issn | 1945-0516 |
| language | English |
| last_indexed | 2024-04-12T20:29:58Z |
| publishDate | 2022-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Scholar |
| spelling | doaj.art-f9a98e52d910489cb63feef6e3ce8cfd2022-12-22T03:17:46ZengIMR PressFrontiers in Bioscience-Scholar1945-05162022-06-011431710.31083/j.fbs1403017S1945-0516(22)00066-1MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in ObesityMaria Vulf0Igor Khlusov1Kristina Yurova2Natalia Todosenko3Alexandra Komar4Ivan Kozlov5Vladimir Malashchenko6Daria Shunkina7Olga Khaziakhmatova8Larisa Litvinova9Center for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaDepartment of Morphology and General Pathology, Siberian State Medical University, 634050 Tomsk, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaDepartment of Organization and Management in the Sphere of Circulation of Medicines, Institute of Postgraduate Education, I.M. Sechenov Federal State Autonomous Educational University of Higher Education—First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaObesity and osteoporosis are global health problems characterized by high rates of prevalence and mortality due to complications. As people with visceral obesity age, the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) increases, and adipocytes become the predominant stromal cells in the bone marrow microenvironment, which hinders the physiological regeneration and mineralization of bone tissue. Primary and secondary osteoporosis remain severe progressive diseases. Both osteoporosis and obesity are associated with microRNAs (miRNAs) that induce adipogenesis and osteoresorption. This review presents analyses of the roles and clinical potential of miRNAs in the epigenetic control of BMSC differentiation and the formation and function of osteoclasts in osteoporosis with and without obesity. Understanding the fine-tuned regulation of the expression of genes critical for the balance of osteogenesis/osteolysis processes may provide hope for the development of effective and safe osteoporosis therapies in the future.https://www.imrpress.com/journal/FBS/14/3/10.31083/j.fbs1403017osteoporosisobesitymsc-bmmicrornaosteoblast |
| spellingShingle | Maria Vulf Igor Khlusov Kristina Yurova Natalia Todosenko Alexandra Komar Ivan Kozlov Vladimir Malashchenko Daria Shunkina Olga Khaziakhmatova Larisa Litvinova MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity Frontiers in Bioscience-Scholar osteoporosis obesity msc-bm microrna osteoblast |
| title | MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity |
| title_full | MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity |
| title_fullStr | MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity |
| title_full_unstemmed | MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity |
| title_short | MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity |
| title_sort | microrna regulation of bone marrow mesenchymal stem cells in the development of osteoporosis in obesity |
| topic | osteoporosis obesity msc-bm microrna osteoblast |
| url | https://www.imrpress.com/journal/FBS/14/3/10.31083/j.fbs1403017 |
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