Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome
Introduction Tranexamic acid, a synthetic anti-fibrinolytic plasminogen inhibitor, a relatively safe drug, is reported to reduce bleeding in various surgical procedures. Our study was to identify the efficacy of tranexamic acid in reducing intraoperative bleeding during tonsillectomy and adeno-t...
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| Format: | Article |
| Language: | English |
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The Association of Otolaryngologists of India, West Bengal
2022-03-01
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| Series: | Bengal Journal of Otolaryngology and Head Neck Surgery |
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| Online Access: | https://www.bjohns.in/journal3/index.php/bjohns/article/view/560 |
| _version_ | 1797226598751010816 |
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| author | Rajarajeswari Nalamate Jishana J Mary Kurien Sajeiv Koshy Mamie Zachariah |
| author_facet | Rajarajeswari Nalamate Jishana J Mary Kurien Sajeiv Koshy Mamie Zachariah |
| author_sort | Rajarajeswari Nalamate |
| collection | DOAJ |
| description |
Introduction
Tranexamic acid, a synthetic anti-fibrinolytic plasminogen inhibitor, a relatively safe drug, is reported to reduce bleeding in various surgical procedures. Our study was to identify the efficacy of tranexamic acid in reducing intraoperative bleeding during tonsillectomy and adeno-tonsillectomy, a common paediatric ENT surgery done as day care procedure.
Materials and Methods
A randomised, placebo controlled, double blinded trial was undertaken with consecutive patients undergoing above procedures, sample size being 100, with 50 patients in each arm. Post induction, injection tranexamic acid 15mg /kg body weight and saline was given to the test and control group respectively. Intraoperative bleeding was measured and operating time was also noted.
Results
There were 80 participants, with 41 and 39 patients in treatment and placebo group respectively ranging from 4 to 32 years age. There was no significant difference in the amount of blood loss between the two groups. However, the duration of surgery was significantly lowered in tranexamic acid as compared to placebo group (p = 0.008).
Conclusions
Preoperative use of tranexamic acid in tonsillectomy or adeno-tonsillectomy, significantly reduced operating time though no significant reduction of intra or postoperative bleeding was noted. This previously unreported outcome has surgical implication, especially in children, for possible use of this widely accepted safe drug during these procedures.
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| first_indexed | 2024-03-09T04:18:32Z |
| format | Article |
| id | doaj.art-f9a9a49180e841828b5f9b7737975bbc |
| institution | Directory Open Access Journal |
| issn | 2395-2407 |
| language | English |
| last_indexed | 2024-04-24T14:27:27Z |
| publishDate | 2022-03-01 |
| publisher | The Association of Otolaryngologists of India, West Bengal |
| record_format | Article |
| series | Bengal Journal of Otolaryngology and Head Neck Surgery |
| spelling | doaj.art-f9a9a49180e841828b5f9b7737975bbc2024-04-03T04:33:25ZengThe Association of Otolaryngologists of India, West BengalBengal Journal of Otolaryngology and Head Neck Surgery2395-24072022-03-01293Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated OutcomeRajarajeswari Nalamate0Jishana J1Mary Kurien2Sajeiv KoshyMamie Zachariah3a:1:{s:5:"en_US";s:54:"Pondicherry Institute of Medical Sciences, Pondicherry";}Pondicherry Institute of Medical Sciences, PondicherryPondicherry Institute of Medical Sciences, PondicherryPondicherry Institute of Medical Sciences, Pondicherry Introduction Tranexamic acid, a synthetic anti-fibrinolytic plasminogen inhibitor, a relatively safe drug, is reported to reduce bleeding in various surgical procedures. Our study was to identify the efficacy of tranexamic acid in reducing intraoperative bleeding during tonsillectomy and adeno-tonsillectomy, a common paediatric ENT surgery done as day care procedure. Materials and Methods A randomised, placebo controlled, double blinded trial was undertaken with consecutive patients undergoing above procedures, sample size being 100, with 50 patients in each arm. Post induction, injection tranexamic acid 15mg /kg body weight and saline was given to the test and control group respectively. Intraoperative bleeding was measured and operating time was also noted. Results There were 80 participants, with 41 and 39 patients in treatment and placebo group respectively ranging from 4 to 32 years age. There was no significant difference in the amount of blood loss between the two groups. However, the duration of surgery was significantly lowered in tranexamic acid as compared to placebo group (p = 0.008). Conclusions Preoperative use of tranexamic acid in tonsillectomy or adeno-tonsillectomy, significantly reduced operating time though no significant reduction of intra or postoperative bleeding was noted. This previously unreported outcome has surgical implication, especially in children, for possible use of this widely accepted safe drug during these procedures. https://www.bjohns.in/journal3/index.php/bjohns/article/view/560AdenoidectomyTonsillectomyHaemorrhageTranexamic AcidOperative Time |
| spellingShingle | Rajarajeswari Nalamate Jishana J Mary Kurien Sajeiv Koshy Mamie Zachariah Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome Bengal Journal of Otolaryngology and Head Neck Surgery Adenoidectomy Tonsillectomy Haemorrhage Tranexamic Acid Operative Time |
| title | Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome |
| title_full | Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome |
| title_fullStr | Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome |
| title_full_unstemmed | Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome |
| title_short | Preoperative Systemic Tranexamic Acid in Tonsillectomy and Adeno-tonsillectomy: A Relevant Underrated Outcome |
| title_sort | preoperative systemic tranexamic acid in tonsillectomy and adeno tonsillectomy a relevant underrated outcome |
| topic | Adenoidectomy Tonsillectomy Haemorrhage Tranexamic Acid Operative Time |
| url | https://www.bjohns.in/journal3/index.php/bjohns/article/view/560 |
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