Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking
Skin aging is a condition caused by reactive oxygen species (ROS) and advanced glycation end products (AGEs). Indonesian gingers (<i>Zingiber officinale</i>), which consists of Gajah (GG), Red (MM), and Emprit (EE) ginger, are thought to produce anti-skin aging compounds through enzyme i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/9/6/128 |
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| author | Shadila F. Asoka Irmanida Batubara Ayu Rahmania Lestari Wulan Tri Wahyuni Setyanto Tri Wahyudi |
| author_facet | Shadila F. Asoka Irmanida Batubara Ayu Rahmania Lestari Wulan Tri Wahyuni Setyanto Tri Wahyudi |
| author_sort | Shadila F. Asoka |
| collection | DOAJ |
| description | Skin aging is a condition caused by reactive oxygen species (ROS) and advanced glycation end products (AGEs). Indonesian gingers (<i>Zingiber officinale</i>), which consists of Gajah (GG), Red (MM), and Emprit (EE) ginger, are thought to produce anti-skin aging compounds through enzyme inhibition. The enzymes used in the molecular docking study were collagenase, hyaluronidase, elastase, and tyrosinase. This study aimed to determine the compounds contained in Indonesian ginger rhizome ethanolic extracts using liquid chromatography–mass spectrometry/mass spectrometry to differentiate metabolites contained in the different Indonesian ginger rhizome extracts. A principal component analysis (PCA) and a heat map analysis were used in order to determine which compounds and extracts contained potential anti-skin aging properties based on a molecular docking study. Ascorbic acid was used as a control ligand in the molecular docking study. Ninety-eight compounds were identified in three different ginger rhizomes extracts and were grouped into three separate quadrants. The most potent compound for anti-skin aging in the Indonesian ginger rhizome extracts was octinoxate. Octinoxate showed a high abundance in the EE ginger rhizome extract. Therefore, the EE ginger extract was the Indonesian ginger rhizome extract with the greatest potential for anti-skin aging. |
| first_indexed | 2024-03-09T17:10:57Z |
| format | Article |
| id | doaj.art-f9aa7124433b4db6ad5a8f68b1b24189 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-09T17:10:57Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-f9aa7124433b4db6ad5a8f68b1b241892023-11-24T14:08:37ZengMDPI AGCosmetics2079-92842022-12-019612810.3390/cosmetics9060128Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular DockingShadila F. Asoka0Irmanida Batubara1Ayu Rahmania Lestari2Wulan Tri Wahyuni3Setyanto Tri Wahyudi4Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, IndonesiaTropical Biopharmaca Research Center, IPB University, Bogor 16128, IndonesiaSkin aging is a condition caused by reactive oxygen species (ROS) and advanced glycation end products (AGEs). Indonesian gingers (<i>Zingiber officinale</i>), which consists of Gajah (GG), Red (MM), and Emprit (EE) ginger, are thought to produce anti-skin aging compounds through enzyme inhibition. The enzymes used in the molecular docking study were collagenase, hyaluronidase, elastase, and tyrosinase. This study aimed to determine the compounds contained in Indonesian ginger rhizome ethanolic extracts using liquid chromatography–mass spectrometry/mass spectrometry to differentiate metabolites contained in the different Indonesian ginger rhizome extracts. A principal component analysis (PCA) and a heat map analysis were used in order to determine which compounds and extracts contained potential anti-skin aging properties based on a molecular docking study. Ascorbic acid was used as a control ligand in the molecular docking study. Ninety-eight compounds were identified in three different ginger rhizomes extracts and were grouped into three separate quadrants. The most potent compound for anti-skin aging in the Indonesian ginger rhizome extracts was octinoxate. Octinoxate showed a high abundance in the EE ginger rhizome extract. Therefore, the EE ginger extract was the Indonesian ginger rhizome extract with the greatest potential for anti-skin aging.https://www.mdpi.com/2079-9284/9/6/128anti-skin agingEmprit gingerLC–MS/MSmolecular dockingPCA |
| spellingShingle | Shadila F. Asoka Irmanida Batubara Ayu Rahmania Lestari Wulan Tri Wahyuni Setyanto Tri Wahyudi Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking Cosmetics anti-skin aging Emprit ginger LC–MS/MS molecular docking PCA |
| title | Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking |
| title_full | Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking |
| title_fullStr | Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking |
| title_full_unstemmed | Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking |
| title_short | Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking |
| title_sort | compounds in indonesian ginger rhizome extracts and their potential for anti skin aging based on molecular docking |
| topic | anti-skin aging Emprit ginger LC–MS/MS molecular docking PCA |
| url | https://www.mdpi.com/2079-9284/9/6/128 |
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