Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh
Abstract Background Despite the wide acceptability of fasting lipid profiles in practice, emerging evidence suggests that random lipid profiles might be a convenient alternative for lipid measurement. The objective of the present study was to compare the fasting and random lipid profile among subjec...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01120-y |
| _version_ | 1797789675554865152 |
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| author | A. B. M. Kamrul-Hasan Samir Kumar Talukder Md Ahamedul Kabir Marufa Mustari Md Masud Un Nabi Abu Jar Gaffar Md Firoj Hossain Muhammad Shah Alam Md Rashedul Islam Mohammad Abdul Hannan Nusrat Zarin Ajit Kumar Paul Farhana Akter Afsar Ahammed Md Lutful Kabir Mohammad Motiur Rahman Md Asaduzzaman Mohammad Saifuddin Palash Kumar Chanda Md Abdur Rafi Mohammad Jahid Hasan Shahjada Selim |
| author_facet | A. B. M. Kamrul-Hasan Samir Kumar Talukder Md Ahamedul Kabir Marufa Mustari Md Masud Un Nabi Abu Jar Gaffar Md Firoj Hossain Muhammad Shah Alam Md Rashedul Islam Mohammad Abdul Hannan Nusrat Zarin Ajit Kumar Paul Farhana Akter Afsar Ahammed Md Lutful Kabir Mohammad Motiur Rahman Md Asaduzzaman Mohammad Saifuddin Palash Kumar Chanda Md Abdur Rafi Mohammad Jahid Hasan Shahjada Selim |
| author_sort | A. B. M. Kamrul-Hasan |
| collection | DOAJ |
| description | Abstract Background Despite the wide acceptability of fasting lipid profiles in practice, emerging evidence suggests that random lipid profiles might be a convenient alternative for lipid measurement. The objective of the present study was to compare the fasting and random lipid profile among subjects with type 2 diabetes mellitus (T2DM). Methods The present cross-sectional study included 1543 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. The fasting lipid profile was measured in the morning following 8–10 h of overnight fasting, and the random lipid profile was measured at any time of the day, irrespective of the last meal. The values of fasting and random lipids were compared using the Wilcoxon signed-rank test and Spearman rank correlation coefficients. Results In this study, a good level of correlation was observed between fasting and random lipid levels [r = 0.793, p < 0.001 for triglyceride (TG); r = 0.873, p < 0.001 for low-density lipoprotein cholesterol (LDL-C); r = 0.609, p < 0.001 for high-density lipoprotein cholesterol (HDL-C); and r = 0.780, p < 0.001 for total cholesterol (TC)]. In addition, TG and TC levels increased by 14% and 0.51%, respectively, in the random state compared to the fasting state (p- <0.05), while LDL-C levels decreased by 0.71% (p-value 0.42). No change was noticed in the HDL-C level. The difference between fasting and random lipid profiles was similar irrespective of patients’ age, sex, BMI, glucose-lowering drug(s), and lipid-lowering therapy. Conclusions Random lipid profile correlates significantly with fasting lipid profile with little difference. Hence, it might be a reliable alternative for fasting lipid profile in patients with T2DM. |
| first_indexed | 2024-03-13T01:54:03Z |
| format | Article |
| id | doaj.art-f9ab399c10c843d6af282dce00c00ced |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-03-13T01:54:03Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-f9ab399c10c843d6af282dce00c00ced2023-07-02T11:21:53ZengBMCDiabetology & Metabolic Syndrome1758-59962023-06-011511910.1186/s13098-023-01120-yComparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in BangladeshA. B. M. Kamrul-Hasan0Samir Kumar Talukder1Md Ahamedul Kabir2Marufa Mustari3Md Masud Un Nabi4Abu Jar Gaffar5Md Firoj Hossain6Muhammad Shah Alam7Md Rashedul Islam8Mohammad Abdul Hannan9Nusrat Zarin10Ajit Kumar Paul11Farhana Akter12Afsar Ahammed13Md Lutful Kabir14Mohammad Motiur Rahman15Md Asaduzzaman16Mohammad Saifuddin17Palash Kumar Chanda18Md Abdur Rafi19Mohammad Jahid Hasan20Shahjada Selim21Department of Endocrinology, Mymensingh Medical CollegeDepartment of Endocrinology, Rangpur Medical CollegeDepartment of Endocrinology, Rangpur Medical CollegeDepartment of Endocrinology, Bangabandhu Sheikh Mujib Medical UniversityDepartment of Endocrinology, Rajshahi Medical CollegeDepartment of Pathology, Naogaon Medical CollegeDepartment of Endocrinology, Mugda Medical CollegeDepartment of Medicine, Army Medical College CumillaDepartment of Neurology, BIRDEM General HospitalDepartment of Endocrinology, North East Medical CollegeDepartment of Endocrinology, Bangladesh Institute of Health SciencesDepartment of Endocrinology, Mainamoti Medical CollegeDepartment of Endocrinology, Chittagong Medical CollegeDepartment of Endocrinology, National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR)Department of Endocrinology, Rangpur Medical CollegeDepartment of Medicine, Rajshahi Medical College HospitalDepartment of Endocrinology, Shaheed Sheikh Abu Naser Specialized HospitalDepartment of Endocrinology, Dhaka Medical CollegeDepartment of Endocrinology, Mymensingh Medical College HospitalPi Research Development CenterPi Research Development CenterDepartment of Endocrinology, Bangabandhu Sheikh Mujib Medical UniversityAbstract Background Despite the wide acceptability of fasting lipid profiles in practice, emerging evidence suggests that random lipid profiles might be a convenient alternative for lipid measurement. The objective of the present study was to compare the fasting and random lipid profile among subjects with type 2 diabetes mellitus (T2DM). Methods The present cross-sectional study included 1543 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. The fasting lipid profile was measured in the morning following 8–10 h of overnight fasting, and the random lipid profile was measured at any time of the day, irrespective of the last meal. The values of fasting and random lipids were compared using the Wilcoxon signed-rank test and Spearman rank correlation coefficients. Results In this study, a good level of correlation was observed between fasting and random lipid levels [r = 0.793, p < 0.001 for triglyceride (TG); r = 0.873, p < 0.001 for low-density lipoprotein cholesterol (LDL-C); r = 0.609, p < 0.001 for high-density lipoprotein cholesterol (HDL-C); and r = 0.780, p < 0.001 for total cholesterol (TC)]. In addition, TG and TC levels increased by 14% and 0.51%, respectively, in the random state compared to the fasting state (p- <0.05), while LDL-C levels decreased by 0.71% (p-value 0.42). No change was noticed in the HDL-C level. The difference between fasting and random lipid profiles was similar irrespective of patients’ age, sex, BMI, glucose-lowering drug(s), and lipid-lowering therapy. Conclusions Random lipid profile correlates significantly with fasting lipid profile with little difference. Hence, it might be a reliable alternative for fasting lipid profile in patients with T2DM.https://doi.org/10.1186/s13098-023-01120-yFasting lipid profileRandom lipid profileT2DMCardiovascular riskLipid-lowering therapy |
| spellingShingle | A. B. M. Kamrul-Hasan Samir Kumar Talukder Md Ahamedul Kabir Marufa Mustari Md Masud Un Nabi Abu Jar Gaffar Md Firoj Hossain Muhammad Shah Alam Md Rashedul Islam Mohammad Abdul Hannan Nusrat Zarin Ajit Kumar Paul Farhana Akter Afsar Ahammed Md Lutful Kabir Mohammad Motiur Rahman Md Asaduzzaman Mohammad Saifuddin Palash Kumar Chanda Md Abdur Rafi Mohammad Jahid Hasan Shahjada Selim Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh Diabetology & Metabolic Syndrome Fasting lipid profile Random lipid profile T2DM Cardiovascular risk Lipid-lowering therapy |
| title | Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh |
| title_full | Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh |
| title_fullStr | Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh |
| title_full_unstemmed | Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh |
| title_short | Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh |
| title_sort | comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus an outpatient based cross sectional study in bangladesh |
| topic | Fasting lipid profile Random lipid profile T2DM Cardiovascular risk Lipid-lowering therapy |
| url | https://doi.org/10.1186/s13098-023-01120-y |
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