Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane
Biological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone, and found highly oriented layers of calcium phos...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/20/4190 |
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| author | YuYang Jiao Masahiro Okada Bhingaradiya Nutan Noriyuki Nagaoka Ahmad Bikharudin Randa Musa Takuya Matsumoto |
| author_facet | YuYang Jiao Masahiro Okada Bhingaradiya Nutan Noriyuki Nagaoka Ahmad Bikharudin Randa Musa Takuya Matsumoto |
| author_sort | YuYang Jiao |
| collection | DOAJ |
| description | Biological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone, and found highly oriented layers of calcium phosphate (CaP) and collagen fibers. To fabricate a fish-rib-bone-mimicking membrane with similar structure and mechanical properties, this study involves (1) the rapid synthesis of plate-like CaP crystals, (2) the layering of CaP–gelatin hydrogels by gradual drying, and (3) controlling the shape of composite membranes using porous gypsum molds. Finally, as a result of optimizing the compositional ratio of CaP filler and gelatin hydrogel, a CaP filler content of 40% provided the optimal mechanical properties of toughness and stiffness similar to fish bone. Due to the rigidity, flexibility, and ease of shape control of the composite membrane materials, this membrane could be applied as a guided bone regeneration (GBR) membrane. |
| first_indexed | 2024-03-10T20:57:10Z |
| format | Article |
| id | doaj.art-f9abe2dfd6454182a18daee5debabd6d |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T20:57:10Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-f9abe2dfd6454182a18daee5debabd6d2023-11-19T17:52:29ZengMDPI AGPolymers2073-43602023-10-011520419010.3390/polym15204190Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite MembraneYuYang Jiao0Masahiro Okada1Bhingaradiya Nutan2Noriyuki Nagaoka3Ahmad Bikharudin4Randa Musa5Takuya Matsumoto6Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanDepartment of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanDepartment of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanAdvanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanDepartment of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanDepartment of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanDepartment of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanBiological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone, and found highly oriented layers of calcium phosphate (CaP) and collagen fibers. To fabricate a fish-rib-bone-mimicking membrane with similar structure and mechanical properties, this study involves (1) the rapid synthesis of plate-like CaP crystals, (2) the layering of CaP–gelatin hydrogels by gradual drying, and (3) controlling the shape of composite membranes using porous gypsum molds. Finally, as a result of optimizing the compositional ratio of CaP filler and gelatin hydrogel, a CaP filler content of 40% provided the optimal mechanical properties of toughness and stiffness similar to fish bone. Due to the rigidity, flexibility, and ease of shape control of the composite membrane materials, this membrane could be applied as a guided bone regeneration (GBR) membrane.https://www.mdpi.com/2073-4360/15/20/4190fish bonelamellar structureself-assemblyguided bone regeneration |
| spellingShingle | YuYang Jiao Masahiro Okada Bhingaradiya Nutan Noriyuki Nagaoka Ahmad Bikharudin Randa Musa Takuya Matsumoto Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane Polymers fish bone lamellar structure self-assembly guided bone regeneration |
| title | Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane |
| title_full | Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane |
| title_fullStr | Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane |
| title_full_unstemmed | Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane |
| title_short | Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane |
| title_sort | fabrication of a fish bone inspired inorganic organic composite membrane |
| topic | fish bone lamellar structure self-assembly guided bone regeneration |
| url | https://www.mdpi.com/2073-4360/15/20/4190 |
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