Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects
Inert microspheres, labeled with several radionuclides, have been developed during the last two decades for the intra-arterial treatment of liver tumors, generally called Selective Intrahepatic radiotherapy (SIRT). The aim is to embolize microspheres into the hepatic capillaries, accessible through...
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3966 |
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| author | Philippe d’Abadie Michel Hesse Amandine Louppe Renaud Lhommel Stephan Walrand Francois Jamar |
| author_facet | Philippe d’Abadie Michel Hesse Amandine Louppe Renaud Lhommel Stephan Walrand Francois Jamar |
| author_sort | Philippe d’Abadie |
| collection | DOAJ |
| description | Inert microspheres, labeled with several radionuclides, have been developed during the last two decades for the intra-arterial treatment of liver tumors, generally called Selective Intrahepatic radiotherapy (SIRT). The aim is to embolize microspheres into the hepatic capillaries, accessible through the hepatic artery, to deliver high levels of local radiation to primary (such as hepatocarcinoma, HCC) or secondary (metastases from several primary cancers, e.g., colorectal, melanoma, neuro-endocrine tumors) liver tumors. Several types of microspheres were designed as medical devices, using different vehicles (glass, resin, poly-lactic acid) and labeled with different radionuclides, <sup>90</sup>Y and <sup>166</sup>Ho. The relationship between the microspheres’ properties and the internal dosimetry parameters have been well studied over the last decade. This includes data derived from the clinics, but also computational data with various millimetric dosimetry and radiobiology models. The main purpose of this paper is to define the characteristics of these radiolabeled microspheres and explain their association with the microsphere distribution in the tissues and with the clinical efficacy and toxicity. This review focuses on avenues to follow in the future to optimize such particle therapy and benefit to patients. |
| first_indexed | 2024-03-10T09:59:15Z |
| format | Article |
| id | doaj.art-f9afe79f219b41a6b20c86d459e82563 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:59:15Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f9afe79f219b41a6b20c86d459e825632023-11-22T02:08:50ZengMDPI AGMolecules1420-30492021-06-012613396610.3390/molecules26133966Microspheres Used in Liver Radioembolization: From Conception to Clinical EffectsPhilippe d’Abadie0Michel Hesse1Amandine Louppe2Renaud Lhommel3Stephan Walrand4Francois Jamar5Department of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumInert microspheres, labeled with several radionuclides, have been developed during the last two decades for the intra-arterial treatment of liver tumors, generally called Selective Intrahepatic radiotherapy (SIRT). The aim is to embolize microspheres into the hepatic capillaries, accessible through the hepatic artery, to deliver high levels of local radiation to primary (such as hepatocarcinoma, HCC) or secondary (metastases from several primary cancers, e.g., colorectal, melanoma, neuro-endocrine tumors) liver tumors. Several types of microspheres were designed as medical devices, using different vehicles (glass, resin, poly-lactic acid) and labeled with different radionuclides, <sup>90</sup>Y and <sup>166</sup>Ho. The relationship between the microspheres’ properties and the internal dosimetry parameters have been well studied over the last decade. This includes data derived from the clinics, but also computational data with various millimetric dosimetry and radiobiology models. The main purpose of this paper is to define the characteristics of these radiolabeled microspheres and explain their association with the microsphere distribution in the tissues and with the clinical efficacy and toxicity. This review focuses on avenues to follow in the future to optimize such particle therapy and benefit to patients.https://www.mdpi.com/1420-3049/26/13/3966liver radioembolizationradiolabeled microspheresdosimetry |
| spellingShingle | Philippe d’Abadie Michel Hesse Amandine Louppe Renaud Lhommel Stephan Walrand Francois Jamar Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects Molecules liver radioembolization radiolabeled microspheres dosimetry |
| title | Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects |
| title_full | Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects |
| title_fullStr | Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects |
| title_full_unstemmed | Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects |
| title_short | Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects |
| title_sort | microspheres used in liver radioembolization from conception to clinical effects |
| topic | liver radioembolization radiolabeled microspheres dosimetry |
| url | https://www.mdpi.com/1420-3049/26/13/3966 |
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