Wolfram syndrome with childhood glaucoma: A rare case report with review of literature
Wolfram syndrome (WFS) is a rare neurodegenerative disorder characterized by young-onset diabetes mellitus, central diabetes insipidus, optic nerve atrophy, and hearing loss. The ophthalmic association of this order has been limited to optic nerve atrophy. We report here a case of WFS and its diseas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Clinical Ophthalmology and Research |
| Subjects: | |
| Online Access: | http://www.jcor.in/article.asp?issn=2320-3897;year=2020;volume=8;issue=3;spage=122;epage=124;aulast=Kesarwani |
| _version_ | 1819295267095052288 |
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| author | Divya Kesarwani Gunjan Jain Sarswati Rachna Agarwal Kumudini Sharma Vaibhav Kumar Jain |
| author_facet | Divya Kesarwani Gunjan Jain Sarswati Rachna Agarwal Kumudini Sharma Vaibhav Kumar Jain |
| author_sort | Divya Kesarwani |
| collection | DOAJ |
| description | Wolfram syndrome (WFS) is a rare neurodegenerative disorder characterized by young-onset diabetes mellitus, central diabetes insipidus, optic nerve atrophy, and hearing loss. The ophthalmic association of this order has been limited to optic nerve atrophy. We report here a case of WFS and its disease course with childhood glaucoma as a rare ophthalmic manifestation which has been reported just once earlier. The patient had young-onset diabetes mellitus (insulin dependent), diabetes insipidus, and optic-disc pallor suggestive of partial optic atrophy. However, hearing assessment was normal at the time of presentation and in due course of disease. Glaucoma is one of the rare possible ocular manifestations of WFS which should be highly considered while evaluating patient with this disorder. |
| first_indexed | 2024-12-24T04:39:30Z |
| format | Article |
| id | doaj.art-f9b003aa5ca943d5acf4ef98c7bc1091 |
| institution | Directory Open Access Journal |
| issn | 2320-3897 |
| language | English |
| last_indexed | 2024-12-24T04:39:30Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj.art-f9b003aa5ca943d5acf4ef98c7bc10912022-12-21T17:14:55ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972020-01-018312212410.4103/jcor.jcor_26_20Wolfram syndrome with childhood glaucoma: A rare case report with review of literatureDivya KesarwaniGunjan JainSarswatiRachna AgarwalKumudini SharmaVaibhav Kumar JainWolfram syndrome (WFS) is a rare neurodegenerative disorder characterized by young-onset diabetes mellitus, central diabetes insipidus, optic nerve atrophy, and hearing loss. The ophthalmic association of this order has been limited to optic nerve atrophy. We report here a case of WFS and its disease course with childhood glaucoma as a rare ophthalmic manifestation which has been reported just once earlier. The patient had young-onset diabetes mellitus (insulin dependent), diabetes insipidus, and optic-disc pallor suggestive of partial optic atrophy. However, hearing assessment was normal at the time of presentation and in due course of disease. Glaucoma is one of the rare possible ocular manifestations of WFS which should be highly considered while evaluating patient with this disorder.http://www.jcor.in/article.asp?issn=2320-3897;year=2020;volume=8;issue=3;spage=122;epage=124;aulast=Kesarwanidiabetes insipidusdiabetes mellitusdidmoad syndromeglaucomaoptic atrophywolfram syndrome |
| spellingShingle | Divya Kesarwani Gunjan Jain Sarswati Rachna Agarwal Kumudini Sharma Vaibhav Kumar Jain Wolfram syndrome with childhood glaucoma: A rare case report with review of literature Journal of Clinical Ophthalmology and Research diabetes insipidus diabetes mellitus didmoad syndrome glaucoma optic atrophy wolfram syndrome |
| title | Wolfram syndrome with childhood glaucoma: A rare case report with review of literature |
| title_full | Wolfram syndrome with childhood glaucoma: A rare case report with review of literature |
| title_fullStr | Wolfram syndrome with childhood glaucoma: A rare case report with review of literature |
| title_full_unstemmed | Wolfram syndrome with childhood glaucoma: A rare case report with review of literature |
| title_short | Wolfram syndrome with childhood glaucoma: A rare case report with review of literature |
| title_sort | wolfram syndrome with childhood glaucoma a rare case report with review of literature |
| topic | diabetes insipidus diabetes mellitus didmoad syndrome glaucoma optic atrophy wolfram syndrome |
| url | http://www.jcor.in/article.asp?issn=2320-3897;year=2020;volume=8;issue=3;spage=122;epage=124;aulast=Kesarwani |
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