Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project
Microphysiological systems (MPS) have been actively developed as a new technology for in vitro toxicity testing platforms in recent years. MPS are culture techniques for the reconstruction of the specific functions of human organs or tissues in a limited space to create miniaturized human test syste...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2021.657765/full |
| _version_ | 1818645568394625024 |
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| author | Seiichi Ishida Seiichi Ishida |
| author_facet | Seiichi Ishida Seiichi Ishida |
| author_sort | Seiichi Ishida |
| collection | DOAJ |
| description | Microphysiological systems (MPS) have been actively developed as a new technology for in vitro toxicity testing platforms in recent years. MPS are culture techniques for the reconstruction of the specific functions of human organs or tissues in a limited space to create miniaturized human test systems. MPS have great promise as next-generation in vitro toxicity assessment systems. Here, I will review the current status of MPS and discuss the requirements that must be met in order for MPS to be implemented in the field of drug discovery, presenting the example of an in vitro cell assay system for drug-induced liver injury, which is the research subject in our laboratory. Projects aimed at the development of MPS were implemented early in Europe and the United States, and the AMED-MPS project was launched in Japan in 2017. The AMED-MPS project involves industry, government, and academia. Researchers in the field of drug discovery in the pharmaceutical industry also participate in the project. Based on the discussions made in the project, I will introduce the requirements that need to be met by liver-MPS as in vitro toxicity test platforms. |
| first_indexed | 2024-12-17T00:32:49Z |
| format | Article |
| id | doaj.art-f9b183d231dc4fdfaa41f56090f82665 |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-12-17T00:32:49Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-f9b183d231dc4fdfaa41f56090f826652022-12-21T22:10:15ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802021-04-01310.3389/ftox.2021.657765657765Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS ProjectSeiichi Ishida0Seiichi Ishida1Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, JapanBiological Safety Research Center, National Institute of Health Sciences, Kawasaki, JapanMicrophysiological systems (MPS) have been actively developed as a new technology for in vitro toxicity testing platforms in recent years. MPS are culture techniques for the reconstruction of the specific functions of human organs or tissues in a limited space to create miniaturized human test systems. MPS have great promise as next-generation in vitro toxicity assessment systems. Here, I will review the current status of MPS and discuss the requirements that must be met in order for MPS to be implemented in the field of drug discovery, presenting the example of an in vitro cell assay system for drug-induced liver injury, which is the research subject in our laboratory. Projects aimed at the development of MPS were implemented early in Europe and the United States, and the AMED-MPS project was launched in Japan in 2017. The AMED-MPS project involves industry, government, and academia. Researchers in the field of drug discovery in the pharmaceutical industry also participate in the project. Based on the discussions made in the project, I will introduce the requirements that need to be met by liver-MPS as in vitro toxicity test platforms.https://www.frontiersin.org/articles/10.3389/ftox.2021.657765/fullmicrophyisiological systemsAMED-MPS projectlong-term exposurecholestasisfibrosisliver zonation |
| spellingShingle | Seiichi Ishida Seiichi Ishida Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project Frontiers in Toxicology microphyisiological systems AMED-MPS project long-term exposure cholestasis fibrosis liver zonation |
| title | Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project |
| title_full | Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project |
| title_fullStr | Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project |
| title_full_unstemmed | Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project |
| title_short | Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project |
| title_sort | research and development of microphysiological systems in japan supported by the amed mps project |
| topic | microphyisiological systems AMED-MPS project long-term exposure cholestasis fibrosis liver zonation |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2021.657765/full |
| work_keys_str_mv | AT seiichiishida researchanddevelopmentofmicrophysiologicalsystemsinjapansupportedbytheamedmpsproject AT seiichiishida researchanddevelopmentofmicrophysiologicalsystemsinjapansupportedbytheamedmpsproject |