A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection
Background: Conventional antifungals are becoming resistant against dermatophytosis due to development of recalcitrant tinea. These patients may get benefit from newer topical antifungals or combination therapy. Topical antifungal therapy is the mainstay in the treatment of dermatophytosis. Aims/Obj...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Drugs in Dermatology |
| Subjects: | |
| Online Access: | http://www.ijdd.in/article.asp?issn=2455-3972;year=2022;volume=8;issue=2;spage=66;epage=72;aulast=Jain |
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| author | Devendra Jain Pradeep Kumar Sanjib Chowdhuri Hitesh Doshi Umesh Jain Savitha L Beergouder Krishnasree Maganti Rashmi Rani Bhagyashree Mohod Ashok Jaiswal |
| author_facet | Devendra Jain Pradeep Kumar Sanjib Chowdhuri Hitesh Doshi Umesh Jain Savitha L Beergouder Krishnasree Maganti Rashmi Rani Bhagyashree Mohod Ashok Jaiswal |
| author_sort | Devendra Jain |
| collection | DOAJ |
| description | Background: Conventional antifungals are becoming resistant against dermatophytosis due to development of recalcitrant tinea. These patients may get benefit from newer topical antifungals or combination therapy. Topical antifungal therapy is the mainstay in the treatment of dermatophytosis. Aims/Objectives: To evaluate the safety and effectiveness of topical amorolfine in tinea infection in real-world settings. Materials and Methods: This was a real-world retrospective study; data was collected from 106 centers across India on the usage of amorolfine in the management of tinea infections. The treatment response was evaluated at the end of 2 and 4 week. It was determined by the reduction in severity of the classic symptoms of disease viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 of treatment. The severity of symptoms was classified and quantified as mild (1), moderate (2), and severe (3). Safety was determined based on the occurrence of any adverse events during the treatment. Results: An improvement in symptoms score was observed for all the classic symptoms of infection viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 compared to baseline. Mean total symptom score (TSS) was reduced to 0.88 ± 1.19 from 7.18 ± 2.84 at week 4 (P < 0.05). Only 10 (0.73%) patients out of 1358 showed mild and non-treatment-related adverse events. Conclusion: Amorolfine alone or in combination therapy with oral antifungals in real world clinical setting represents an improved treatment strategy for patients with tinea infections. |
| first_indexed | 2024-04-10T09:57:11Z |
| format | Article |
| id | doaj.art-f9b2b18157354dbda2e2e6bc93f245a1 |
| institution | Directory Open Access Journal |
| issn | 2455-3972 |
| language | English |
| last_indexed | 2024-04-10T09:57:11Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Drugs in Dermatology |
| spelling | doaj.art-f9b2b18157354dbda2e2e6bc93f245a12023-02-16T12:19:44ZengWolters Kluwer Medknow PublicationsIndian Journal of Drugs in Dermatology2455-39722022-01-0182667210.4103/ijdd.ijdd_8_22A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infectionDevendra JainPradeep KumarSanjib ChowdhuriHitesh DoshiUmesh JainSavitha L BeergouderKrishnasree MagantiRashmi RaniBhagyashree MohodAshok JaiswalBackground: Conventional antifungals are becoming resistant against dermatophytosis due to development of recalcitrant tinea. These patients may get benefit from newer topical antifungals or combination therapy. Topical antifungal therapy is the mainstay in the treatment of dermatophytosis. Aims/Objectives: To evaluate the safety and effectiveness of topical amorolfine in tinea infection in real-world settings. Materials and Methods: This was a real-world retrospective study; data was collected from 106 centers across India on the usage of amorolfine in the management of tinea infections. The treatment response was evaluated at the end of 2 and 4 week. It was determined by the reduction in severity of the classic symptoms of disease viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 of treatment. The severity of symptoms was classified and quantified as mild (1), moderate (2), and severe (3). Safety was determined based on the occurrence of any adverse events during the treatment. Results: An improvement in symptoms score was observed for all the classic symptoms of infection viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 compared to baseline. Mean total symptom score (TSS) was reduced to 0.88 ± 1.19 from 7.18 ± 2.84 at week 4 (P < 0.05). Only 10 (0.73%) patients out of 1358 showed mild and non-treatment-related adverse events. Conclusion: Amorolfine alone or in combination therapy with oral antifungals in real world clinical setting represents an improved treatment strategy for patients with tinea infections.http://www.ijdd.in/article.asp?issn=2455-3972;year=2022;volume=8;issue=2;spage=66;epage=72;aulast=Jaindermatophytosisitraconazolereal-world studysymptoms scoretopical amorolfine |
| spellingShingle | Devendra Jain Pradeep Kumar Sanjib Chowdhuri Hitesh Doshi Umesh Jain Savitha L Beergouder Krishnasree Maganti Rashmi Rani Bhagyashree Mohod Ashok Jaiswal A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection Indian Journal of Drugs in Dermatology dermatophytosis itraconazole real-world study symptoms score topical amorolfine |
| title | A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| title_full | A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| title_fullStr | A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| title_full_unstemmed | A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| title_short | A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| title_sort | retrospective analysis of real world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection |
| topic | dermatophytosis itraconazole real-world study symptoms score topical amorolfine |
| url | http://www.ijdd.in/article.asp?issn=2455-3972;year=2022;volume=8;issue=2;spage=66;epage=72;aulast=Jain |
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