Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/7/2050 |
| _version_ | 1797538935151263744 |
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| author | Eugene V. Babaev Ivan A. Shadrin |
| author_facet | Eugene V. Babaev Ivan A. Shadrin |
| author_sort | Eugene V. Babaev |
| collection | DOAJ |
| description | Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed. |
| first_indexed | 2024-03-10T12:38:14Z |
| format | Article |
| id | doaj.art-f9b2ebdc73e941af8adc943c41ccd7b7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:38:14Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f9b2ebdc73e941af8adc943c41ccd7b72023-11-21T14:06:26ZengMDPI AGMolecules1420-30492021-04-01267205010.3390/molecules26072050Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] CycloadditionEugene V. Babaev0Ivan A. Shadrin1Chemistry Department, Moscow State University, Leninskie Gory, 1 Str. 3, 119899 Moscow, RussiaChemistry Department, Moscow State University, Leninskie Gory, 1 Str. 3, 119899 Moscow, RussiaPeculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed.https://www.mdpi.com/1420-3049/26/7/2050indolizineazaindolizinesbenzoindolizinescyclazine[8+2] cycloadditionmechanism |
| spellingShingle | Eugene V. Babaev Ivan A. Shadrin Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition Molecules indolizine azaindolizines benzoindolizines cyclazine [8+2] cycloaddition mechanism |
| title | Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition |
| title_full | Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition |
| title_fullStr | Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition |
| title_full_unstemmed | Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition |
| title_short | Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition |
| title_sort | indolizines and their hetero benzo derivatives in reactions of 8 2 cycloaddition |
| topic | indolizine azaindolizines benzoindolizines cyclazine [8+2] cycloaddition mechanism |
| url | https://www.mdpi.com/1420-3049/26/7/2050 |
| work_keys_str_mv | AT eugenevbabaev indolizinesandtheirheterobenzoderivativesinreactionsof82cycloaddition AT ivanashadrin indolizinesandtheirheterobenzoderivativesinreactionsof82cycloaddition |