1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel

Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 C...

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Main Authors: Tadeusz F. Molinski, Isaac N. Pessah, Alexander C. Hoepker, Makoto N. Masuno
Format: Article
Language:English
Published: MDPI AG 2004-11-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/2/4/176/
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author Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
author_facet Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
author_sort Tadeusz F. Molinski
collection DOAJ
description Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).
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spelling doaj.art-f9b5ed81d861454b977f3402f159cb652022-12-22T02:58:40ZengMDPI AGMarine Drugs1660-33972004-11-012417618410.3390/md2041761-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ ChannelTadeusz F. MolinskiIsaac N. PessahAlexander C. HoepkerMakoto N. MasunoAbstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).http://www.mdpi.com/1660-3397/2/4/176/Bromotyrosinecalcium channelPoriferaryanodine receptor
spellingShingle Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
Marine Drugs
Bromotyrosine
calcium channel
Porifera
ryanodine receptor
title 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_full 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_fullStr 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_full_unstemmed 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_short 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_sort 1 o sulfatobastadins 1 and 2 from ianthella basta pallas antagonists of the yr1 fkbp12 ca2 channel
topic Bromotyrosine
calcium channel
Porifera
ryanodine receptor
url http://www.mdpi.com/1660-3397/2/4/176/
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