1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 C...
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Format: | Article |
Language: | English |
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MDPI AG
2004-11-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-3397/2/4/176/ |
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author | Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno |
author_facet | Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno |
author_sort | Tadeusz F. Molinski |
collection | DOAJ |
description | Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM). |
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format | Article |
id | doaj.art-f9b5ed81d861454b977f3402f159cb65 |
institution | Directory Open Access Journal |
issn | 1660-3397 |
language | English |
last_indexed | 2024-04-13T06:20:27Z |
publishDate | 2004-11-01 |
publisher | MDPI AG |
record_format | Article |
series | Marine Drugs |
spelling | doaj.art-f9b5ed81d861454b977f3402f159cb652022-12-22T02:58:40ZengMDPI AGMarine Drugs1660-33972004-11-012417618410.3390/md2041761-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ ChannelTadeusz F. MolinskiIsaac N. PessahAlexander C. HoepkerMakoto N. MasunoAbstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).http://www.mdpi.com/1660-3397/2/4/176/Bromotyrosinecalcium channelPoriferaryanodine receptor |
spellingShingle | Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel Marine Drugs Bromotyrosine calcium channel Porifera ryanodine receptor |
title | 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_full | 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_fullStr | 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_full_unstemmed | 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_short | 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_sort | 1 o sulfatobastadins 1 and 2 from ianthella basta pallas antagonists of the yr1 fkbp12 ca2 channel |
topic | Bromotyrosine calcium channel Porifera ryanodine receptor |
url | http://www.mdpi.com/1660-3397/2/4/176/ |
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