Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation
Background: It is known that hypoxic pulmonary vasoconstriction increases as a result of intermittent regional hypoxic challenges. The aim of this study was to compare the effects of sevoflurane and propofol on oxygenation and shunt fraction during one-lung ventilation in a novel model of hypoxic pr...
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Language: | English |
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Elsevier
2014-03-01
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Series: | Brazilian Journal of Anesthesiology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001413001085 |
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author | Ayşe Karci Seden Duru Hasan Hepağuşlar Lügen Çiftçi Osman Yilmaz |
author_facet | Ayşe Karci Seden Duru Hasan Hepağuşlar Lügen Çiftçi Osman Yilmaz |
author_sort | Ayşe Karci |
collection | DOAJ |
description | Background: It is known that hypoxic pulmonary vasoconstriction increases as a result of intermittent regional hypoxic challenges. The aim of this study was to compare the effects of sevoflurane and propofol on oxygenation and shunt fraction during one-lung ventilation in a novel model of hypoxic preconditioning before one-lung ventilation. Methods: Sixteen Wistar-albino rats were anesthetized intra-peritoneally before venous and arterial cannulations and tracheotomized. The animals were randomly allocated to receive either sevoflurane 2% or 10 mg/kg/h propofol infusion and ventilated with 100% oxygen at an inspiratory rate of 80 breaths/min for 30 min. Three cycles of one-lung ventilation and two-lung ventilation were performed and one-lung ventilation was continued for 15 min. Arterial blood gas samples were obtained as follows: after cannulation and tracheotomy, following 30 min of treatment with sevoflurane or propofol, and at the 5th and 15th min of one-lung ventilation. Results: The PaO2 levels were higher and shunt fractions were lower in rats receiving propofol compared to rats treated with sevoflurane but the difference was not significant; the two groups were comparable in terms of PaCO2. Conclusions: The similar effects of sevoflurane and propofol on PaO2 during one-lung ventilation following hypoxic preconditioning may be due to other causes beside the inhibition of hypoxic pulmonary vasoconstriction. Gradual transition to one-lung ventilation is a novel technique for preconditioning experiments for one-lung ventilation. Keywords: One-lung ventilation, Gradual transition, Sevoflurane propofol |
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id | doaj.art-f9b5ee5a1aa3442482d48246cfabb02f |
institution | Directory Open Access Journal |
issn | 0104-0014 |
language | English |
last_indexed | 2024-04-12T02:23:56Z |
publishDate | 2014-03-01 |
publisher | Elsevier |
record_format | Article |
series | Brazilian Journal of Anesthesiology |
spelling | doaj.art-f9b5ee5a1aa3442482d48246cfabb02f2022-12-22T03:52:04ZengElsevierBrazilian Journal of Anesthesiology0104-00142014-03-016427983Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilationAyşe Karci0Seden Duru1Hasan Hepağuşlar2Lügen Çiftçi3Osman Yilmaz4Department of Anesthesiology and Reanimation, Medical School, Dokuz Eylul University, İzmir, Turkey; Corresponding author.Department of Anesthesiology and Reanimation, Medical School, Dokuz Eylul University, İzmir, TurkeyDepartment of Anesthesiology and Reanimation, Medical School, Dokuz Eylul University, İzmir, TurkeyDepartment of Anesthesiology, State Hospital, Denizli, TurkeyDepartment of Laboratory Animal Science, Medical School, Dokuz Eylul University, Inciralti, İzmir, TurkeyBackground: It is known that hypoxic pulmonary vasoconstriction increases as a result of intermittent regional hypoxic challenges. The aim of this study was to compare the effects of sevoflurane and propofol on oxygenation and shunt fraction during one-lung ventilation in a novel model of hypoxic preconditioning before one-lung ventilation. Methods: Sixteen Wistar-albino rats were anesthetized intra-peritoneally before venous and arterial cannulations and tracheotomized. The animals were randomly allocated to receive either sevoflurane 2% or 10 mg/kg/h propofol infusion and ventilated with 100% oxygen at an inspiratory rate of 80 breaths/min for 30 min. Three cycles of one-lung ventilation and two-lung ventilation were performed and one-lung ventilation was continued for 15 min. Arterial blood gas samples were obtained as follows: after cannulation and tracheotomy, following 30 min of treatment with sevoflurane or propofol, and at the 5th and 15th min of one-lung ventilation. Results: The PaO2 levels were higher and shunt fractions were lower in rats receiving propofol compared to rats treated with sevoflurane but the difference was not significant; the two groups were comparable in terms of PaCO2. Conclusions: The similar effects of sevoflurane and propofol on PaO2 during one-lung ventilation following hypoxic preconditioning may be due to other causes beside the inhibition of hypoxic pulmonary vasoconstriction. Gradual transition to one-lung ventilation is a novel technique for preconditioning experiments for one-lung ventilation. Keywords: One-lung ventilation, Gradual transition, Sevoflurane propofolhttp://www.sciencedirect.com/science/article/pii/S0104001413001085 |
spellingShingle | Ayşe Karci Seden Duru Hasan Hepağuşlar Lügen Çiftçi Osman Yilmaz Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation Brazilian Journal of Anesthesiology |
title | Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation |
title_full | Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation |
title_fullStr | Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation |
title_full_unstemmed | Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation |
title_short | Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation |
title_sort | comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one lung ventilation |
url | http://www.sciencedirect.com/science/article/pii/S0104001413001085 |
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