Regional variation in brain tissue texture in patients with tonic-clonic seizures.
Patients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274514 |
| _version_ | 1827932874980982784 |
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| author | Jennifer A Ogren Luke A Allen Bhaswati Roy Beate Diehl John M Stern Dawn S Eliashiv Samden D Lhatoo Ronald M Harper Rajesh Kumar |
| author_facet | Jennifer A Ogren Luke A Allen Bhaswati Roy Beate Diehl John M Stern Dawn S Eliashiv Samden D Lhatoo Ronald M Harper Rajesh Kumar |
| author_sort | Jennifer A Ogren |
| collection | DOAJ |
| description | Patients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess the source of volume changes (e.g., neuronal loss or glial cell swelling). We assessed a measure, entropy, which can determine tissue homogeneity by evaluating tissue randomness, and thus, shows tissue integrity; the measure is easily calculated from T1-weighted images. T1-weighted images were collected with a 3.0-Tesla MRI from 53 patients with tonic-clonic (TC) seizures and 53 healthy controls; images were bias-corrected, entropy maps calculated, normalized to a common space, smoothed, and compared between groups (TC patients and controls using ANCOVA; covariates, age and sex; SPM12, family-wise error correction for multiple comparisons, p<0.01). Decreased entropy, indicative of increased tissue homogeneity, appeared in major autonomic (ventromedial prefrontal cortex, hippocampus, dorsal and ventral medulla, deep cerebellar nuclei), motor (sensory and motor cortex), or both motor and autonomic regulatory sites (basal-ganglia, ventral-basal cerebellum), and external surfaces of the pons. The anterior and posterior thalamus and midbrain also showed entropy declines. Only a few isolated regions showed increased entropy. Among the spared autonomic regions was the anterior cingulate and anterior insula; the posterior insula and cingulate were, however, affected. The entropy alterations overlapped areas of tissue changes found earlier with volumetric measures, but were more extensive, and indicate widespread injury to tissue within critical autonomic and breathing regulatory areas, as well as prominent damage to more-rostral sites that exert influences on both breathing and cardiovascular regulation. The entropy measures provide easily-collected supplementary information using only T1-weighted images, showing aspects of tissue integrity other than volume change that are important for assessing function. |
| first_indexed | 2024-03-13T07:16:35Z |
| format | Article |
| id | doaj.art-f9ba37d38a2b41de8bdc8ee5fe3b02bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T07:16:35Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f9ba37d38a2b41de8bdc8ee5fe3b02bd2023-06-05T05:32:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027451410.1371/journal.pone.0274514Regional variation in brain tissue texture in patients with tonic-clonic seizures.Jennifer A OgrenLuke A AllenBhaswati RoyBeate DiehlJohn M SternDawn S EliashivSamden D LhatooRonald M HarperRajesh KumarPatients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess the source of volume changes (e.g., neuronal loss or glial cell swelling). We assessed a measure, entropy, which can determine tissue homogeneity by evaluating tissue randomness, and thus, shows tissue integrity; the measure is easily calculated from T1-weighted images. T1-weighted images were collected with a 3.0-Tesla MRI from 53 patients with tonic-clonic (TC) seizures and 53 healthy controls; images were bias-corrected, entropy maps calculated, normalized to a common space, smoothed, and compared between groups (TC patients and controls using ANCOVA; covariates, age and sex; SPM12, family-wise error correction for multiple comparisons, p<0.01). Decreased entropy, indicative of increased tissue homogeneity, appeared in major autonomic (ventromedial prefrontal cortex, hippocampus, dorsal and ventral medulla, deep cerebellar nuclei), motor (sensory and motor cortex), or both motor and autonomic regulatory sites (basal-ganglia, ventral-basal cerebellum), and external surfaces of the pons. The anterior and posterior thalamus and midbrain also showed entropy declines. Only a few isolated regions showed increased entropy. Among the spared autonomic regions was the anterior cingulate and anterior insula; the posterior insula and cingulate were, however, affected. The entropy alterations overlapped areas of tissue changes found earlier with volumetric measures, but were more extensive, and indicate widespread injury to tissue within critical autonomic and breathing regulatory areas, as well as prominent damage to more-rostral sites that exert influences on both breathing and cardiovascular regulation. The entropy measures provide easily-collected supplementary information using only T1-weighted images, showing aspects of tissue integrity other than volume change that are important for assessing function.https://doi.org/10.1371/journal.pone.0274514 |
| spellingShingle | Jennifer A Ogren Luke A Allen Bhaswati Roy Beate Diehl John M Stern Dawn S Eliashiv Samden D Lhatoo Ronald M Harper Rajesh Kumar Regional variation in brain tissue texture in patients with tonic-clonic seizures. PLoS ONE |
| title | Regional variation in brain tissue texture in patients with tonic-clonic seizures. |
| title_full | Regional variation in brain tissue texture in patients with tonic-clonic seizures. |
| title_fullStr | Regional variation in brain tissue texture in patients with tonic-clonic seizures. |
| title_full_unstemmed | Regional variation in brain tissue texture in patients with tonic-clonic seizures. |
| title_short | Regional variation in brain tissue texture in patients with tonic-clonic seizures. |
| title_sort | regional variation in brain tissue texture in patients with tonic clonic seizures |
| url | https://doi.org/10.1371/journal.pone.0274514 |
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