Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis

Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis

Background: The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by assessment of in vivo effects of these compounds on depressive and anxious behavior. Methods: The docking between apigenin a...

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Bibliographic Details
Main Authors: Faiq Amin, Mahmoud A. A. Ibrahim, Syed Rizwan-ul-Hasan, Saima Khaliq, Gamal A. Gabr, Muhammad, Asra Khan, Peter A. Sidhom, Prashant Tikmani, Ahmed M. Shawky, Saara Ahmad, Syed Hani Abidi
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
depression
anxiety
natural compounds
molecular docking and dynamics
serotonin receptors
murine model
Online Access:https://www.mdpi.com/1420-3049/27/24/8658

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