Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_19257_2dddd886b301d5e6bedb157dc42ecd8d.pdf |
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| author | Mohammadreza Abbaspour Pariya Iraji Zahra Mahmoudi Niloufar Rahiman Abbas Akhgari |
| author_facet | Mohammadreza Abbaspour Pariya Iraji Zahra Mahmoudi Niloufar Rahiman Abbas Akhgari |
| author_sort | Mohammadreza Abbaspour |
| collection | DOAJ |
| description | Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With this dosage form, the drug dissolves rapidly in saliva and is absorbed readily without the need for water. Materials and Methods: For this purpose, valsartan with polyvinylpyrrolidone (PVPK90) polymer were exposed to the electrospinning technique to construct orodispersible nanofilms. The optimum obtained nanofiber, selected by Design-Expert software, was evaluated in terms of mechanical strength for evaluation of the flexibility and fragility of the nanofibers. The drug content, wettability, and disintegration tests, as well as the release assessment of the nanofibers, were performed followed by DSC, FTIR, and XRD assays.Results: The uniform nanofibers’ diameter increased with the increase of the polymer concentration. The tensile test verified a stress reduction at the yield point as the polymer concentration increased. Then, the 492 nm nanofiber with above 90% drug encapsulation, containing 8% polymer and 18% valsartan made below 9 kV, was selected. The wetting time was less than 30 sec and over 90% of the drug was released in less than 2 min. The XRD and DSC studies also confirmed higher valsartan solubility due to the construction alternations in nanofibers. The FTIR examination indicated the chemical bonding between the drug and the polymer.Conclusion: The selected nanofibers of valsartan present the essential drug feature and acceptable drug release for further investigations. |
| first_indexed | 2024-12-23T13:23:24Z |
| format | Article |
| id | doaj.art-f9ba986a4e11422abba6d9243bbd35a9 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-23T13:23:24Z |
| publishDate | 2021-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-f9ba986a4e11422abba6d9243bbd35a92022-12-21T17:45:23ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742021-12-0124121683169410.22038/ijbms.2021.58713.1304119257Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning methodMohammadreza Abbaspour0Pariya Iraji1Zahra Mahmoudi2Niloufar Rahiman3Abbas Akhgari4Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With this dosage form, the drug dissolves rapidly in saliva and is absorbed readily without the need for water. Materials and Methods: For this purpose, valsartan with polyvinylpyrrolidone (PVPK90) polymer were exposed to the electrospinning technique to construct orodispersible nanofilms. The optimum obtained nanofiber, selected by Design-Expert software, was evaluated in terms of mechanical strength for evaluation of the flexibility and fragility of the nanofibers. The drug content, wettability, and disintegration tests, as well as the release assessment of the nanofibers, were performed followed by DSC, FTIR, and XRD assays.Results: The uniform nanofibers’ diameter increased with the increase of the polymer concentration. The tensile test verified a stress reduction at the yield point as the polymer concentration increased. Then, the 492 nm nanofiber with above 90% drug encapsulation, containing 8% polymer and 18% valsartan made below 9 kV, was selected. The wetting time was less than 30 sec and over 90% of the drug was released in less than 2 min. The XRD and DSC studies also confirmed higher valsartan solubility due to the construction alternations in nanofibers. The FTIR examination indicated the chemical bonding between the drug and the polymer.Conclusion: The selected nanofibers of valsartan present the essential drug feature and acceptable drug release for further investigations.https://ijbms.mums.ac.ir/article_19257_2dddd886b301d5e6bedb157dc42ecd8d.pdfhypertensionnanofiberpolymerspolyvinylpyrrolidonevalsartan |
| spellingShingle | Mohammadreza Abbaspour Pariya Iraji Zahra Mahmoudi Niloufar Rahiman Abbas Akhgari Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method Iranian Journal of Basic Medical Sciences hypertension nanofiber polymers polyvinylpyrrolidone valsartan |
| title | Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method |
| title_full | Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method |
| title_fullStr | Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method |
| title_full_unstemmed | Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method |
| title_short | Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method |
| title_sort | design and physico mechanical evaluation of fast dissolving valsartan polymeric drug delivery system by electrospinning method |
| topic | hypertension nanofiber polymers polyvinylpyrrolidone valsartan |
| url | https://ijbms.mums.ac.ir/article_19257_2dddd886b301d5e6bedb157dc42ecd8d.pdf |
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