Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance
A major outbreak of yellow fever (YF) occurred in Brazil during 2016–2018. Epizootics in New World nonhuman primates are sentinel events for YF virus circulation. However, genus-specific susceptibilities and suitability for YF surveillance remain poorly understood. We obtained and compared epidemiol...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/1/19-1220_article |
| _version_ | 1818789232729128960 |
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| author | Natália C.C. de Azevedo Fernandes Juliana M. Guerra Josué Díaz-Delgado Mariana S. Cunha Leila delC. Saad Silvia D. Iglezias Rodrigo A. Ressio Cinthya dos Santos Cirqueira Cristina T. Kanamura Isis P. Jesus Adriana Y. Maeda Fernanda G.S. Vasami Júlia de Carvalho Leonardo J.T. de Araújo Renato Pereira de Souza Juliana S. Nogueira Roberta M.F. Spinola José L. Catão-Dias |
| author_facet | Natália C.C. de Azevedo Fernandes Juliana M. Guerra Josué Díaz-Delgado Mariana S. Cunha Leila delC. Saad Silvia D. Iglezias Rodrigo A. Ressio Cinthya dos Santos Cirqueira Cristina T. Kanamura Isis P. Jesus Adriana Y. Maeda Fernanda G.S. Vasami Júlia de Carvalho Leonardo J.T. de Araújo Renato Pereira de Souza Juliana S. Nogueira Roberta M.F. Spinola José L. Catão-Dias |
| author_sort | Natália C.C. de Azevedo Fernandes |
| collection | DOAJ |
| description | A major outbreak of yellow fever (YF) occurred in Brazil during 2016–2018. Epizootics in New World nonhuman primates are sentinel events for YF virus circulation. However, genus-specific susceptibilities and suitability for YF surveillance remain poorly understood. We obtained and compared epidemiologic, histopathologic, immunohistochemical, and molecular results from 93 human and 1,752 primate cases submitted during the recent YF outbreak in Brazil (2017), with the support of the Brazilian National YF Surveillance Program. We detected heterogeneous YF-associated profiles among the various genera of primates we analyzed. Alouatta primates were the most reliable sentinel; Sapajus and Callicebus primates had higher viral loads but lower proportional mortality rates. Callithrix primates were the least sensitive, showing lower viral loads, lower proportional mortality rates, and no demonstrable YF virus antigen or extensive lesions in liver, despite detectable viral RNA. These differences in susceptibility, viral load, and mortality rates should be considered in strategic surveillance of epizootics and control measures for YF. |
| first_indexed | 2024-12-18T14:36:18Z |
| format | Article |
| id | doaj.art-f9bcb758cebf4649abd968ed1b62c852 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-18T14:36:18Z |
| publishDate | 2021-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f9bcb758cebf4649abd968ed1b62c8522022-12-21T21:04:30ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-01-01271475610.3201/eid2701.191220Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for SurveillanceNatália C.C. de Azevedo FernandesJuliana M. GuerraJosué Díaz-DelgadoMariana S. CunhaLeila delC. SaadSilvia D. IgleziasRodrigo A. RessioCinthya dos Santos CirqueiraCristina T. KanamuraIsis P. JesusAdriana Y. MaedaFernanda G.S. VasamiJúlia de CarvalhoLeonardo J.T. de AraújoRenato Pereira de SouzaJuliana S. NogueiraRoberta M.F. SpinolaJosé L. Catão-DiasA major outbreak of yellow fever (YF) occurred in Brazil during 2016–2018. Epizootics in New World nonhuman primates are sentinel events for YF virus circulation. However, genus-specific susceptibilities and suitability for YF surveillance remain poorly understood. We obtained and compared epidemiologic, histopathologic, immunohistochemical, and molecular results from 93 human and 1,752 primate cases submitted during the recent YF outbreak in Brazil (2017), with the support of the Brazilian National YF Surveillance Program. We detected heterogeneous YF-associated profiles among the various genera of primates we analyzed. Alouatta primates were the most reliable sentinel; Sapajus and Callicebus primates had higher viral loads but lower proportional mortality rates. Callithrix primates were the least sensitive, showing lower viral loads, lower proportional mortality rates, and no demonstrable YF virus antigen or extensive lesions in liver, despite detectable viral RNA. These differences in susceptibility, viral load, and mortality rates should be considered in strategic surveillance of epizootics and control measures for YF.https://wwwnc.cdc.gov/eid/article/27/1/19-1220_articleyellow feveryellow fever virusvirusesarbovirusesliverdifferential susceptibility |
| spellingShingle | Natália C.C. de Azevedo Fernandes Juliana M. Guerra Josué Díaz-Delgado Mariana S. Cunha Leila delC. Saad Silvia D. Iglezias Rodrigo A. Ressio Cinthya dos Santos Cirqueira Cristina T. Kanamura Isis P. Jesus Adriana Y. Maeda Fernanda G.S. Vasami Júlia de Carvalho Leonardo J.T. de Araújo Renato Pereira de Souza Juliana S. Nogueira Roberta M.F. Spinola José L. Catão-Dias Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance Emerging Infectious Diseases yellow fever yellow fever virus viruses arboviruses liver differential susceptibility |
| title | Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance |
| title_full | Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance |
| title_fullStr | Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance |
| title_full_unstemmed | Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance |
| title_short | Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance |
| title_sort | differential yellow fever susceptibility in new world nonhuman primates comparison with humans and implications for surveillance |
| topic | yellow fever yellow fever virus viruses arboviruses liver differential susceptibility |
| url | https://wwwnc.cdc.gov/eid/article/27/1/19-1220_article |
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