Developing and maintaining a nose-to-brain map of odorant identity
Olfactory sensory neurons (OSNs) in the olfactory epithelium of the nose transduce chemical odorant stimuli into electrical signals. These signals are then sent to the OSNs' target structure in the brain, the main olfactory bulb (OB), which performs the initial stages of sensory processing in o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2022-06-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.220053 |
| _version_ | 1797974528389808128 |
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| author | Ana Dorrego-Rivas Matthew S. Grubb |
| author_facet | Ana Dorrego-Rivas Matthew S. Grubb |
| author_sort | Ana Dorrego-Rivas |
| collection | DOAJ |
| description | Olfactory sensory neurons (OSNs) in the olfactory epithelium of the nose transduce chemical odorant stimuli into electrical signals. These signals are then sent to the OSNs' target structure in the brain, the main olfactory bulb (OB), which performs the initial stages of sensory processing in olfaction. The projection of OSNs to the OB is highly organized in a chemospatial map, whereby axon terminals from OSNs expressing the same odorant receptor (OR) coalesce into individual spherical structures known as glomeruli. This nose-to-brain map of odorant identity is built from late embryonic development to early postnatal life, through a complex combination of genetically encoded, OR-dependent and activity-dependent mechanisms. It must then be actively maintained throughout adulthood as OSNs experience turnover due to external insult and ongoing neurogenesis. Our review describes and discusses these two distinct and crucial processes in olfaction, focusing on the known mechanisms that first establish and then maintain chemospatial order in the mammalian OSN-to-OB projection. |
| first_indexed | 2024-04-11T04:21:12Z |
| format | Article |
| id | doaj.art-f9bebf027281447a97b3866e18834848 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-11T04:21:12Z |
| publishDate | 2022-06-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-f9bebf027281447a97b3866e188348482022-12-30T17:14:13ZengThe Royal SocietyOpen Biology2046-24412022-06-0112610.1098/rsob.220053Developing and maintaining a nose-to-brain map of odorant identityAna Dorrego-Rivas0Matthew S. Grubb1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UKOlfactory sensory neurons (OSNs) in the olfactory epithelium of the nose transduce chemical odorant stimuli into electrical signals. These signals are then sent to the OSNs' target structure in the brain, the main olfactory bulb (OB), which performs the initial stages of sensory processing in olfaction. The projection of OSNs to the OB is highly organized in a chemospatial map, whereby axon terminals from OSNs expressing the same odorant receptor (OR) coalesce into individual spherical structures known as glomeruli. This nose-to-brain map of odorant identity is built from late embryonic development to early postnatal life, through a complex combination of genetically encoded, OR-dependent and activity-dependent mechanisms. It must then be actively maintained throughout adulthood as OSNs experience turnover due to external insult and ongoing neurogenesis. Our review describes and discusses these two distinct and crucial processes in olfaction, focusing on the known mechanisms that first establish and then maintain chemospatial order in the mammalian OSN-to-OB projection.https://royalsocietypublishing.org/doi/10.1098/rsob.220053olfactionolfactory sensory neuronsodorant receptorsolfactory bulbaxon guidancedevelopment |
| spellingShingle | Ana Dorrego-Rivas Matthew S. Grubb Developing and maintaining a nose-to-brain map of odorant identity Open Biology olfaction olfactory sensory neurons odorant receptors olfactory bulb axon guidance development |
| title | Developing and maintaining a nose-to-brain map of odorant identity |
| title_full | Developing and maintaining a nose-to-brain map of odorant identity |
| title_fullStr | Developing and maintaining a nose-to-brain map of odorant identity |
| title_full_unstemmed | Developing and maintaining a nose-to-brain map of odorant identity |
| title_short | Developing and maintaining a nose-to-brain map of odorant identity |
| title_sort | developing and maintaining a nose to brain map of odorant identity |
| topic | olfaction olfactory sensory neurons odorant receptors olfactory bulb axon guidance development |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.220053 |
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