Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance.
<h4>Introduction</h4>Moderate hypoxia may impact cognitive and sensorimotor performance prior to self-recognized impairments. Therefore, rapid and objective assessment tools to identify people at risk of impaired function during moderate hypoxia is needed.<h4>Purpose</h4>Test...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297486&type=printable |
| _version_ | 1797292860351971328 |
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| author | Jason M Keeler Jennifer B Listman M Jo Hite David J Heeger Erica Tourula Nicholas L Port Zachary J Schlader |
| author_facet | Jason M Keeler Jennifer B Listman M Jo Hite David J Heeger Erica Tourula Nicholas L Port Zachary J Schlader |
| author_sort | Jason M Keeler |
| collection | DOAJ |
| description | <h4>Introduction</h4>Moderate hypoxia may impact cognitive and sensorimotor performance prior to self-recognized impairments. Therefore, rapid and objective assessment tools to identify people at risk of impaired function during moderate hypoxia is needed.<h4>Purpose</h4>Test the hypothesis that reductions in arterial oxygen saturation during moderate normobaric hypoxia (FiO2 = 14%) decreases gamified sensorimotor performance as measured by alterations of motor acuity.<h4>Methods</h4>Following three consecutive days of practice, thirty healthy adults (25 ± 5 y, 10 females) completed three bouts of the tablet-based gamified assessment (Statespace Labs, Inc.) of motor acuity at Baseline and 60 and 90 min after exposure to 13.8 ± 0.2% (hypoxia) and 20.1 ± 0.4% (normoxia) oxygen. The gamified assessment involved moving the tablet to aim and shoot at targets. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Performance metrics included shot time and shot variability. Arterial oxyhemoglobin saturation estimated via forehead pulse oximetry (SpO2). Data were analyzed using linear mixed effects models.<h4>Results</h4>Compared to normoxia (99±1%), SpO2 was lower (p<0.001) at 60 (89±3%) and 90 (90±2%) min of hypoxia. Shot time was unaffected by decreases in SpO2 (0.012, p = 0.19). Nor was shot time affected by the interaction between SpO2 decrease and baseline performance (0.006, p = 0.46). Shot variability was greater (i.e., less precision, worse performance) with decreases in SpO2 (0.023, p = 0.02) and depended on the interaction between SpO2 decrease and baseline performance (0.029, p< 0.01).<h4>Conclusion</h4>Decreases in SpO2 during moderate hypoxic exposure hinders sensorimotor performance via decreased motor acuity, i.e., greater variability (less precision) with no change in speed with differing decreases in SpO2. Thus, personnel who are exposed to moderate hypoxia and have greater decreases in SpO2 exhibit lower motor acuity, i.e., less precise movements even though decision time and movement speed are unaffected. |
| first_indexed | 2024-03-07T20:03:39Z |
| format | Article |
| id | doaj.art-f9bfa11b81934d6cab96146bd1dea51c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T20:03:39Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-f9bfa11b81934d6cab96146bd1dea51c2024-02-28T05:31:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029748610.1371/journal.pone.0297486Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance.Jason M KeelerJennifer B ListmanM Jo HiteDavid J HeegerErica TourulaNicholas L PortZachary J Schlader<h4>Introduction</h4>Moderate hypoxia may impact cognitive and sensorimotor performance prior to self-recognized impairments. Therefore, rapid and objective assessment tools to identify people at risk of impaired function during moderate hypoxia is needed.<h4>Purpose</h4>Test the hypothesis that reductions in arterial oxygen saturation during moderate normobaric hypoxia (FiO2 = 14%) decreases gamified sensorimotor performance as measured by alterations of motor acuity.<h4>Methods</h4>Following three consecutive days of practice, thirty healthy adults (25 ± 5 y, 10 females) completed three bouts of the tablet-based gamified assessment (Statespace Labs, Inc.) of motor acuity at Baseline and 60 and 90 min after exposure to 13.8 ± 0.2% (hypoxia) and 20.1 ± 0.4% (normoxia) oxygen. The gamified assessment involved moving the tablet to aim and shoot at targets. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Performance metrics included shot time and shot variability. Arterial oxyhemoglobin saturation estimated via forehead pulse oximetry (SpO2). Data were analyzed using linear mixed effects models.<h4>Results</h4>Compared to normoxia (99±1%), SpO2 was lower (p<0.001) at 60 (89±3%) and 90 (90±2%) min of hypoxia. Shot time was unaffected by decreases in SpO2 (0.012, p = 0.19). Nor was shot time affected by the interaction between SpO2 decrease and baseline performance (0.006, p = 0.46). Shot variability was greater (i.e., less precision, worse performance) with decreases in SpO2 (0.023, p = 0.02) and depended on the interaction between SpO2 decrease and baseline performance (0.029, p< 0.01).<h4>Conclusion</h4>Decreases in SpO2 during moderate hypoxic exposure hinders sensorimotor performance via decreased motor acuity, i.e., greater variability (less precision) with no change in speed with differing decreases in SpO2. Thus, personnel who are exposed to moderate hypoxia and have greater decreases in SpO2 exhibit lower motor acuity, i.e., less precise movements even though decision time and movement speed are unaffected.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297486&type=printable |
| spellingShingle | Jason M Keeler Jennifer B Listman M Jo Hite David J Heeger Erica Tourula Nicholas L Port Zachary J Schlader Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. PLoS ONE |
| title | Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. |
| title_full | Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. |
| title_fullStr | Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. |
| title_full_unstemmed | Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. |
| title_short | Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance. |
| title_sort | arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297486&type=printable |
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