Elevated liver enzymes associated with dronedarone for atrial fibrillation
A 51-year-old male with documented atrial fibrillation who was taking dronedarone 400 mg twice daily for approximately 3 months returned to the cardiologist for an ablation procedure. Baseline liver enzymes were within normal range prior to starting the medication and increased after the 3 months of...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-11-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X13511600 |
| _version_ | 1819010612840103936 |
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| author | Kelly R Ragucci |
| author_facet | Kelly R Ragucci |
| author_sort | Kelly R Ragucci |
| collection | DOAJ |
| description | A 51-year-old male with documented atrial fibrillation who was taking dronedarone 400 mg twice daily for approximately 3 months returned to the cardiologist for an ablation procedure. Baseline liver enzymes were within normal range prior to starting the medication and increased after the 3 months of therapy. Aspartate aminotransferase increased from 31 IU/L to 98 IU/L, and alanine aminotransferase increased from 21 IU/L to 101 IU/L. Two and a half months after discontinuation of the medication, liver enzymes normalized (aspartate aminotransferase: 30 IU/L and alanine aminotransferase: 25 IU/L). The Food and Drug Administration has now alerted health-care professionals of the potential for liver injury based upon post-marketing surveillance. The chronological course of elevated liver enzymes noted in our patient is suggestive of a dronedarone-induced problem. Clinicians should have a heightened awareness of the potential for liver enzyme elevation and injury with dronedarone and should monitor enzymes periodically, especially within the first 6 months of use. |
| first_indexed | 2024-12-21T01:15:02Z |
| format | Article |
| id | doaj.art-f9c02755ef5e48b68988091567450805 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-21T01:15:02Z |
| publishDate | 2013-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-f9c02755ef5e48b689880915674508052022-12-21T19:20:49ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2013-11-01110.1177/2050313X1351160010.1177_2050313X13511600Elevated liver enzymes associated with dronedarone for atrial fibrillationKelly R RagucciA 51-year-old male with documented atrial fibrillation who was taking dronedarone 400 mg twice daily for approximately 3 months returned to the cardiologist for an ablation procedure. Baseline liver enzymes were within normal range prior to starting the medication and increased after the 3 months of therapy. Aspartate aminotransferase increased from 31 IU/L to 98 IU/L, and alanine aminotransferase increased from 21 IU/L to 101 IU/L. Two and a half months after discontinuation of the medication, liver enzymes normalized (aspartate aminotransferase: 30 IU/L and alanine aminotransferase: 25 IU/L). The Food and Drug Administration has now alerted health-care professionals of the potential for liver injury based upon post-marketing surveillance. The chronological course of elevated liver enzymes noted in our patient is suggestive of a dronedarone-induced problem. Clinicians should have a heightened awareness of the potential for liver enzyme elevation and injury with dronedarone and should monitor enzymes periodically, especially within the first 6 months of use.https://doi.org/10.1177/2050313X13511600 |
| spellingShingle | Kelly R Ragucci Elevated liver enzymes associated with dronedarone for atrial fibrillation SAGE Open Medical Case Reports |
| title | Elevated liver enzymes associated with dronedarone for atrial fibrillation |
| title_full | Elevated liver enzymes associated with dronedarone for atrial fibrillation |
| title_fullStr | Elevated liver enzymes associated with dronedarone for atrial fibrillation |
| title_full_unstemmed | Elevated liver enzymes associated with dronedarone for atrial fibrillation |
| title_short | Elevated liver enzymes associated with dronedarone for atrial fibrillation |
| title_sort | elevated liver enzymes associated with dronedarone for atrial fibrillation |
| url | https://doi.org/10.1177/2050313X13511600 |
| work_keys_str_mv | AT kellyrragucci elevatedliverenzymesassociatedwithdronedaroneforatrialfibrillation |