| Summary: | This study present the solid state synthesis of Copper (II) and Nickel (II) Complexes of Rhodanine with molecular formula [Cu(HRD)2(CH3COO)2] represented as 1a and [Ni(HRD)2(NO3)2] (HRD = C3H3NOS2) represented as 2a. It was synthesized by mechanochemical grinding of stoichiometric amount of Rhodanine with inorganic salts (Cu(CH3COO)2·H2O) and Ni(NO3)2·6H2O in ratio 1:1 via an analytical mortar and pestle without solvent. However, the solvent based approach for the synthesis of Copper (II) and Nickel (II) Complexes of Rhodanine involve the use methanol at room temperature. The complexes were characterized via elemental analysis, TLC, FT-IR, UV–visible, AAS, spectroscopies, conductivity measurement and PXRD patterns. The spectroscopic and analytical data obtained from the two methods are almost identical. The PXRD patterns of the product obtained from the solid state approach showed a close match with that of the solvent-based product. The complexes showed new peaks which established the occurrence of a new phase. The antibacterial activities of the complexes were higher than the parent ligands. This suggested that the antimicrobial efficacy of these drugs could be improved by chelation. The solid based synthesis of these complexes was faster, required less energy and produce better yield when compared with the solvent based method.
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