Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy
Acute kidney injury (AKI) is related to mortality and morbidity. The De Ritis ratio, calculated by dividing the aspartate aminotransferase by the alanine aminotransferase, is used as a prognostic indicator. We evaluated risk factors for AKI after radical retropubic prostatectomy (RRP). This retrospe...
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MDPI AG
2021-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/9/836 |
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| author | Jun-Young Park Jihion Yu Jun Hyuk Hong Bumjin Lim Youngdo Kim Jai-Hyun Hwang Young-Kug Kim |
| author_facet | Jun-Young Park Jihion Yu Jun Hyuk Hong Bumjin Lim Youngdo Kim Jai-Hyun Hwang Young-Kug Kim |
| author_sort | Jun-Young Park |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is related to mortality and morbidity. The De Ritis ratio, calculated by dividing the aspartate aminotransferase by the alanine aminotransferase, is used as a prognostic indicator. We evaluated risk factors for AKI after radical retropubic prostatectomy (RRP). This retrospective study included patients who performed RRP. Multivariable logistic regression analysis and a receiver operating characteristic (ROC) curve analysis were conducted. Other postoperative outcomes were also evaluated. Among the 1415 patients, 77 (5.4%) had AKI postoperatively. The multivariable logistic regression analysis showed that estimated glomerular filtration rate, albumin level, and the De Ritis ratio at postoperative day 1 were risk factors for AKI. The area under the ROC curve of the De Ritis ratio at postoperative day 1 was 0.801 (cutoff = 1.2). Multivariable-adjusted analysis revealed that the De Ritis ratio at ≥1.2 was significantly related to AKI (odds ratio = 8.637, <i>p</i> < 0.001). Postoperative AKI was associated with longer hospitalization duration (11 ± 5 days vs. 10 ± 4 days, <i>p</i> = 0.002). These results collectively show that an elevated De Ritis ratio at postoperative day 1 is associated with AKI after RRP in patients with prostate cancer. |
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| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T07:32:28Z |
| publishDate | 2021-08-01 |
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| spelling | doaj.art-f9c0b8f89786433c9a2a95332f3e42cd2023-11-22T13:49:51ZengMDPI AGJournal of Personalized Medicine2075-44262021-08-0111983610.3390/jpm11090836Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic ProstatectomyJun-Young Park0Jihion Yu1Jun Hyuk Hong2Bumjin Lim3Youngdo Kim4Jai-Hyun Hwang5Young-Kug Kim6Asan Medical Center, Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Urology, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Urology, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAsan Medical Center, Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Seoul 05505, KoreaAcute kidney injury (AKI) is related to mortality and morbidity. The De Ritis ratio, calculated by dividing the aspartate aminotransferase by the alanine aminotransferase, is used as a prognostic indicator. We evaluated risk factors for AKI after radical retropubic prostatectomy (RRP). This retrospective study included patients who performed RRP. Multivariable logistic regression analysis and a receiver operating characteristic (ROC) curve analysis were conducted. Other postoperative outcomes were also evaluated. Among the 1415 patients, 77 (5.4%) had AKI postoperatively. The multivariable logistic regression analysis showed that estimated glomerular filtration rate, albumin level, and the De Ritis ratio at postoperative day 1 were risk factors for AKI. The area under the ROC curve of the De Ritis ratio at postoperative day 1 was 0.801 (cutoff = 1.2). Multivariable-adjusted analysis revealed that the De Ritis ratio at ≥1.2 was significantly related to AKI (odds ratio = 8.637, <i>p</i> < 0.001). Postoperative AKI was associated with longer hospitalization duration (11 ± 5 days vs. 10 ± 4 days, <i>p</i> = 0.002). These results collectively show that an elevated De Ritis ratio at postoperative day 1 is associated with AKI after RRP in patients with prostate cancer.https://www.mdpi.com/2075-4426/11/9/836prostate cancerradical retropubic prostatectomyDe Ritis ratioacute kidney injury |
| spellingShingle | Jun-Young Park Jihion Yu Jun Hyuk Hong Bumjin Lim Youngdo Kim Jai-Hyun Hwang Young-Kug Kim Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy Journal of Personalized Medicine prostate cancer radical retropubic prostatectomy De Ritis ratio acute kidney injury |
| title | Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy |
| title_full | Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy |
| title_fullStr | Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy |
| title_full_unstemmed | Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy |
| title_short | Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy |
| title_sort | elevated de ritis ratio as a predictor for acute kidney injury after radical retropubic prostatectomy |
| topic | prostate cancer radical retropubic prostatectomy De Ritis ratio acute kidney injury |
| url | https://www.mdpi.com/2075-4426/11/9/836 |
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