Mutations in <it>LRP5 </it>cause primary osteoporosis without features of OI by reducing Wnt signaling activity

Mutations in <it>LRP5 </it>cause primary osteoporosis without features of OI by reducing Wnt signaling activity

<p>Abstract</p> <p>Background</p> <p>Primary osteoporosis is a rare childhood-onset skeletal condition whose pathogenesis has been largely unknown. We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lip...

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Main Authors: Korvala Johanna, Jüppner Harald, Mäkitie Outi, Sochett Etienne, Schnabel Dirk, Mora Stefano, Bartels Cynthia F, Warman Matthew L, Deraska Donald, Cole William G, Hartikka Heini, Ala-Kokko Leena, Männikkö Minna
Format: Article
Language:English
Published: BMC 2012-04-01
Series:BMC Medical Genetics
Online Access:http://www.biomedcentral.com/1471-2350/13/26

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