Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis
Introduction: Biological reconstruction techniques in sarcoma surgery are employed selectively within limb-sparing procedures. The utilization of extracorporeal irradiated bone autografts stands as a secure, cost-efficient, and efficacious therapeutic approach. Surgical site infection in such cases...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-09-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-532-539.pdf |
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| author | Hüseyin KAYA Arman VAHABİ Merve MERT VAHABİ Serra KAMER Dündar SABAH Meltem TAŞBAKAN |
| author_facet | Hüseyin KAYA Arman VAHABİ Merve MERT VAHABİ Serra KAMER Dündar SABAH Meltem TAŞBAKAN |
| author_sort | Hüseyin KAYA |
| collection | DOAJ |
| description | Introduction: Biological reconstruction techniques in sarcoma surgery are employed selectively within limb-sparing procedures. The utilization of extracorporeal irradiated bone autografts stands as a secure, cost-efficient, and efficacious therapeutic approach. Surgical site infection in such cases is associated with graft failure, necessitating further surgical intervention, consequently raising the morbidity rate.
Materials and Methods: This study adopted a retrospective cohort design, encompassing the timeline from January 2002 to December 2020. Data on demographic charateristics, structural attributes of the graft employed, infection-related complications, culture results, instances of secondary surgical intervention, and occurrences of graft loss were noted. Infections are classified as superficial or deep, and instances of graft loss are categorized as partial or complete.
Results: Surgical site infections occurred in 39 out of 180 patients (21.6%). The pelvis (n= 19, 48.7%) and tibia (n= 9, 23%) constituted the most frequent locations for these occurrences. Among 29 culture growths, Acinetobacter baumannii (n= 8, 27.5%) and Escherichia coli (n= 6, 20.7%) were the predominant isolates. Among the infected cases, complete graft loss was observed in 18 (46.1%), while partial graft loss occurred in eight (20.5%).
Conclusion: To the best of our knowledge, this data is one of the largest patient series reported in the literature. Intraoperative and postoperative variables need to be optimized in these patients to reduce graft loss and morbidity. Postoperative surgical site-related complications should be addressed promptly with early debridement and appropriate antibiotic therapy. |
| first_indexed | 2024-03-11T22:36:29Z |
| format | Article |
| id | doaj.art-f9c1c2238d3d4c0fb11cd0fc0a7b0d5c |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-03-11T22:36:29Z |
| publishDate | 2023-09-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-f9c1c2238d3d4c0fb11cd0fc0a7b0d5c2023-09-22T13:43:46ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-09-0128353253910.5578/flora.20239725Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort AnalysisHüseyin KAYA0https://orcid.org/0000-0003-1415-1654Arman VAHABİ1https://orcid.org/0000-0003-1415-1654Merve MERT VAHABİ2https://orcid.org/0000-0002-5008-0139Serra KAMER3https://orcid.org/0000-0001-8316-9976Dündar SABAH4https://orcid.org/0000-0002-3391-2597Meltem TAŞBAKAN5https://orcid.org/0000-0002-4689-720XDepartment of Orthopedics and Traumatology, Ege University Faculty of Medicine, İzmir, TürkiyeDepartment of Orthopedics and Traumatology, Ege University Faculty of Medicine, İzmir, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, İzmir, TürkiyeDepartment of Radiation Oncology, Ege University Faculty of Medicine, İzmir, TürkiyeDepartment of Orthopedics and Traumatology, Ege University Faculty of Medicine, İzmir, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, İzmir, TürkiyeIntroduction: Biological reconstruction techniques in sarcoma surgery are employed selectively within limb-sparing procedures. The utilization of extracorporeal irradiated bone autografts stands as a secure, cost-efficient, and efficacious therapeutic approach. Surgical site infection in such cases is associated with graft failure, necessitating further surgical intervention, consequently raising the morbidity rate. Materials and Methods: This study adopted a retrospective cohort design, encompassing the timeline from January 2002 to December 2020. Data on demographic charateristics, structural attributes of the graft employed, infection-related complications, culture results, instances of secondary surgical intervention, and occurrences of graft loss were noted. Infections are classified as superficial or deep, and instances of graft loss are categorized as partial or complete. Results: Surgical site infections occurred in 39 out of 180 patients (21.6%). The pelvis (n= 19, 48.7%) and tibia (n= 9, 23%) constituted the most frequent locations for these occurrences. Among 29 culture growths, Acinetobacter baumannii (n= 8, 27.5%) and Escherichia coli (n= 6, 20.7%) were the predominant isolates. Among the infected cases, complete graft loss was observed in 18 (46.1%), while partial graft loss occurred in eight (20.5%). Conclusion: To the best of our knowledge, this data is one of the largest patient series reported in the literature. Intraoperative and postoperative variables need to be optimized in these patients to reduce graft loss and morbidity. Postoperative surgical site-related complications should be addressed promptly with early debridement and appropriate antibiotic therapy. http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-532-539.pdfbone tumorlocomotor systemmalignancyradiation therapyinfection |
| spellingShingle | Hüseyin KAYA Arman VAHABİ Merve MERT VAHABİ Serra KAMER Dündar SABAH Meltem TAŞBAKAN Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi bone tumor locomotor system malignancy radiation therapy infection |
| title | Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis |
| title_full | Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis |
| title_fullStr | Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis |
| title_full_unstemmed | Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis |
| title_short | Surgical Site Infection in Sarcoma Patients Treated with Extracorporeal Irradiated Bone Autograft: A 18-Year Cohort Analysis |
| title_sort | surgical site infection in sarcoma patients treated with extracorporeal irradiated bone autograft a 18 year cohort analysis |
| topic | bone tumor locomotor system malignancy radiation therapy infection |
| url | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-532-539.pdf |
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