Fic and non-Fic AMPylases: protein AMPylation in metazoans
Protein AMPylation refers to the covalent attachment of an AMP moiety to the amino acid side chains of target proteins using ATP as nucleotide donor. This process is catalysed by dedicated AMP transferases, called AMPylases. Since this initial discovery, several research groups have identified AMPyl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-05-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.210009 |
| _version_ | 1811190752534855680 |
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| author | Bhaskar K. Chatterjee Matthias C. Truttmann |
| author_facet | Bhaskar K. Chatterjee Matthias C. Truttmann |
| author_sort | Bhaskar K. Chatterjee |
| collection | DOAJ |
| description | Protein AMPylation refers to the covalent attachment of an AMP moiety to the amino acid side chains of target proteins using ATP as nucleotide donor. This process is catalysed by dedicated AMP transferases, called AMPylases. Since this initial discovery, several research groups have identified AMPylation as a critical post-translational modification relevant to normal and pathological cell signalling in both bacteria and metazoans. Bacterial AMPylases are abundant enzymes that either regulate the function of endogenous bacterial proteins or are translocated into host cells to hijack host cell signalling processes. By contrast, only two classes of metazoan AMPylases have been identified so far: enzymes containing a conserved filamentation induced by cAMP (Fic) domain (Fic AMPylases), which primarily modify the ER-resident chaperone BiP, and SelO, a mitochondrial AMPylase involved in redox signalling. In this review, we compare and contrast bacterial and metazoan Fic and non-Fic AMPylases, and summarize recent technological and conceptual developments in the emerging field of AMPylation. |
| first_indexed | 2024-04-11T14:54:29Z |
| format | Article |
| id | doaj.art-f9c1edc0d48a4b4883ae3044dbdc57bb |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-11T14:54:29Z |
| publishDate | 2021-05-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-f9c1edc0d48a4b4883ae3044dbdc57bb2022-12-22T04:17:18ZengThe Royal SocietyOpen Biology2046-24412021-05-0111510.1098/rsob.210009Fic and non-Fic AMPylases: protein AMPylation in metazoansBhaskar K. Chatterjee0Matthias C. Truttmann1Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USACellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USAProtein AMPylation refers to the covalent attachment of an AMP moiety to the amino acid side chains of target proteins using ATP as nucleotide donor. This process is catalysed by dedicated AMP transferases, called AMPylases. Since this initial discovery, several research groups have identified AMPylation as a critical post-translational modification relevant to normal and pathological cell signalling in both bacteria and metazoans. Bacterial AMPylases are abundant enzymes that either regulate the function of endogenous bacterial proteins or are translocated into host cells to hijack host cell signalling processes. By contrast, only two classes of metazoan AMPylases have been identified so far: enzymes containing a conserved filamentation induced by cAMP (Fic) domain (Fic AMPylases), which primarily modify the ER-resident chaperone BiP, and SelO, a mitochondrial AMPylase involved in redox signalling. In this review, we compare and contrast bacterial and metazoan Fic and non-Fic AMPylases, and summarize recent technological and conceptual developments in the emerging field of AMPylation.https://royalsocietypublishing.org/doi/10.1098/rsob.210009post-translational modificationfilamentation induced by cAMPnon-Ficampylaseschaperone and neurodegeneration |
| spellingShingle | Bhaskar K. Chatterjee Matthias C. Truttmann Fic and non-Fic AMPylases: protein AMPylation in metazoans Open Biology post-translational modification filamentation induced by cAMP non-Fic ampylases chaperone and neurodegeneration |
| title | Fic and non-Fic AMPylases: protein AMPylation in metazoans |
| title_full | Fic and non-Fic AMPylases: protein AMPylation in metazoans |
| title_fullStr | Fic and non-Fic AMPylases: protein AMPylation in metazoans |
| title_full_unstemmed | Fic and non-Fic AMPylases: protein AMPylation in metazoans |
| title_short | Fic and non-Fic AMPylases: protein AMPylation in metazoans |
| title_sort | fic and non fic ampylases protein ampylation in metazoans |
| topic | post-translational modification filamentation induced by cAMP non-Fic ampylases chaperone and neurodegeneration |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.210009 |
| work_keys_str_mv | AT bhaskarkchatterjee ficandnonficampylasesproteinampylationinmetazoans AT matthiasctruttmann ficandnonficampylasesproteinampylationinmetazoans |