Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy
Purpose: To analyze the ocular surface changes in eyes after the withdrawal of anti-glaucomatous drugs when non-penetrating deep sclerectomy (NPDS) is performed. Methods: Thirty-one patients (33 eyes) diagnosed with glaucoma that underwent NPDS were included in this prospective study. The control gr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1626;epage=1633;aulast=Fuente-García |
| _version_ | 1811244791015407616 |
|---|---|
| author | Carlota Fuente-García Francisco José Muñoz-Negrete Elisabet de Dompablo Javier Moreno-Montañés Gema Rebolleda |
| author_facet | Carlota Fuente-García Francisco José Muñoz-Negrete Elisabet de Dompablo Javier Moreno-Montañés Gema Rebolleda |
| author_sort | Carlota Fuente-García |
| collection | DOAJ |
| description | Purpose: To analyze the ocular surface changes in eyes after the withdrawal of anti-glaucomatous drugs when non-penetrating deep sclerectomy (NPDS) is performed. Methods: Thirty-one patients (33 eyes) diagnosed with glaucoma that underwent NPDS were included in this prospective study. The control group included 33 eyes. Four variables were studied using Keratograph 5M (K5M): ocular hyperemia (OH), non-invasive tear film break-up time (NI-BUT), lower tear meniscus height (LTMH), and meibography. LTMH was also measured using the anterior segment module of a Spectralis Fourier-domain optical coherence tomography (FD-OCT) instrument. Moreover, an evaluation of corneal and conjunctival staining was performed. In the glaucoma group, five visits were carried out: pre-surgery, 1 week after surgery, and 1 month, 3 months, and 6 months after surgery. In control groups, examinations were performed in only one visit. In addition, patients were asked to answer two questionnaires: Ocular Surface Disease Index (OSDI) and National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) before and 6 months after surgery. Results: Before NPDS, eyes showed worse objective data than healthy control subjects (P ≤ 0.049). In this group, a significant improvement was observed in questionnaire responses (P < 0.001), LTMH-FD-OCT (P = 0.037), LTMH-K5M (P = 0.025), K5M-OH (P = 0.003), NI-BUT (P = 0.022), and conjunctival and corneal staining (P < 0.001). No significant differences were observed between groups in FD-OCT and K5M LTMH, NI-BUT, corneal-conjunctival staining, nor in the most OH sector values at 6 months (P ≥ 0.62). Conclusion: A significant improvement in the ocular surface was observed 6 months after NPDS, suggesting that the withdrawal of the topical anti-glaucomatous treatment had a beneficial effect on the subjects. |
| first_indexed | 2024-04-12T14:31:06Z |
| format | Article |
| id | doaj.art-f9c20c4d0580427aa091b750dbe2f3a5 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-12T14:31:06Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-f9c20c4d0580427aa091b750dbe2f3a52022-12-22T03:29:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017051626163310.4103/ijo.IJO_2654_21Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomyCarlota Fuente-GarcíaFrancisco José Muñoz-NegreteElisabet de DompabloJavier Moreno-MontañésGema RebolledaPurpose: To analyze the ocular surface changes in eyes after the withdrawal of anti-glaucomatous drugs when non-penetrating deep sclerectomy (NPDS) is performed. Methods: Thirty-one patients (33 eyes) diagnosed with glaucoma that underwent NPDS were included in this prospective study. The control group included 33 eyes. Four variables were studied using Keratograph 5M (K5M): ocular hyperemia (OH), non-invasive tear film break-up time (NI-BUT), lower tear meniscus height (LTMH), and meibography. LTMH was also measured using the anterior segment module of a Spectralis Fourier-domain optical coherence tomography (FD-OCT) instrument. Moreover, an evaluation of corneal and conjunctival staining was performed. In the glaucoma group, five visits were carried out: pre-surgery, 1 week after surgery, and 1 month, 3 months, and 6 months after surgery. In control groups, examinations were performed in only one visit. In addition, patients were asked to answer two questionnaires: Ocular Surface Disease Index (OSDI) and National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) before and 6 months after surgery. Results: Before NPDS, eyes showed worse objective data than healthy control subjects (P ≤ 0.049). In this group, a significant improvement was observed in questionnaire responses (P < 0.001), LTMH-FD-OCT (P = 0.037), LTMH-K5M (P = 0.025), K5M-OH (P = 0.003), NI-BUT (P = 0.022), and conjunctival and corneal staining (P < 0.001). No significant differences were observed between groups in FD-OCT and K5M LTMH, NI-BUT, corneal-conjunctival staining, nor in the most OH sector values at 6 months (P ≥ 0.62). Conclusion: A significant improvement in the ocular surface was observed 6 months after NPDS, suggesting that the withdrawal of the topical anti-glaucomatous treatment had a beneficial effect on the subjects.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1626;epage=1633;aulast=Fuente-Garcíaglaucomakeratographnon-penetrating deep sclerectomyocular hyperemiaocular surface disease |
| spellingShingle | Carlota Fuente-García Francisco José Muñoz-Negrete Elisabet de Dompablo Javier Moreno-Montañés Gema Rebolleda Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy Indian Journal of Ophthalmology glaucoma keratograph non-penetrating deep sclerectomy ocular hyperemia ocular surface disease |
| title | Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy |
| title_full | Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy |
| title_fullStr | Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy |
| title_full_unstemmed | Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy |
| title_short | Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy |
| title_sort | changes in ocular surface after withdrawal of anti glaucoma medications following non penetrating deep sclerectomy |
| topic | glaucoma keratograph non-penetrating deep sclerectomy ocular hyperemia ocular surface disease |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=5;spage=1626;epage=1633;aulast=Fuente-García |
| work_keys_str_mv | AT carlotafuentegarcia changesinocularsurfaceafterwithdrawalofantiglaucomamedicationsfollowingnonpenetratingdeepsclerectomy AT franciscojosemunoznegrete changesinocularsurfaceafterwithdrawalofantiglaucomamedicationsfollowingnonpenetratingdeepsclerectomy AT elisabetdedompablo changesinocularsurfaceafterwithdrawalofantiglaucomamedicationsfollowingnonpenetratingdeepsclerectomy AT javiermorenomontanes changesinocularsurfaceafterwithdrawalofantiglaucomamedicationsfollowingnonpenetratingdeepsclerectomy AT gemarebolleda changesinocularsurfaceafterwithdrawalofantiglaucomamedicationsfollowingnonpenetratingdeepsclerectomy |