Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA p.G608G splice variant that leads to the expression of a permanently farnesylated abnormal form of prelamin-A, refer...

Full description

Bibliographic Details
Main Authors: Guillaume Bidault, Marie Garcia, Jacqueline Capeau, Romain Morichon, Corinne Vigouroux, Véronique Béréziat
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
Hutchinson–Gilford progeria syndrome
<i>LMNA</i>
progerin
lamin A
atherosclerosis
endothelial dysfunction
Online Access:https://www.mdpi.com/2073-4409/9/5/1201

Similar Items

Similar Items