Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats

Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats

Previous studies have shown that genetically selected Marchigian Sardinian alcohol-preferring (msP) rats consume excessive amounts of ethanol to self-medicate from negative moods and to relieve innate hypersensitivity to stress. This phenotype resembling a subset of alcohol use disorder (AUD) patien...

Full description

Bibliographic Details
Main Authors:	Francesca Felicia Caputi, Serena Stopponi, Laura Rullo, Martina Palmisano, Massimo Ubaldi, Sanzio Candeletti, Roberto Ciccocioppo, Patrizia Romualdi
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	International Journal of Molecular Sciences
Subjects:	addiction ethanol nociceptin dynorphin BDNF CRF
Online Access:	https://www.mdpi.com/1422-0067/22/5/2448

Similar Items

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders
by: Massimo Ubaldi, et al.
Published: (2021-11-01)

Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain
by: Amal El Daibani, et al.
Published: (2022-01-01)

Plasma concentrations of nociceptin/orphanin FQ: comparison of levels after general and neuraxial anesthesia for arthroscopic knee surgery
by: Heeseung Lee, et al.
Published: (2013-10-01)

Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours
by: Omar N. Al Yacoub, et al.
Published: (2024-01-01)

Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD
by: Zhang Yong, et al.
Published: (2012-10-01)

Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin/orphanin FQ peptide receptor in rats
by: Fangmin Wang, et al.
Published: (2022-10-01)

Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice
by: Victor A.D. Holanda, et al.
Published: (2020-11-01)

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions
by: Krystyna Pierzchała-Koziec, et al.
Published: (2023-06-01)

Nociceptin/Orphanin FQ receptor expression in primary human umbilical vein endothelial cells is not regulated by exposure to breast cancer cell media or angiogenic stimuli
by: Despina Giakomidi, et al.
Published: (2022-12-01)

Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner
by: Jennifer Hernandez, et al.
Published: (2019-02-01)

The Nociceptin/Orphanin FQ peptide receptor antagonist, SB-612111, improves cerebral blood flow in a rat model of traumatic brain injury
by: Omar N. Al Yacoub, et al.
Published: (2023-10-01)

Interactions between the Nociceptin and Toll-like Receptor Systems
by: Lan Zhang, et al.
Published: (2022-03-01)

The Role of Orphanin FQ/Nociceptin in Neuroplasticity: Relationship to Stress, Anxiety and Neuroinflammation
by: Elyse M Mallimo, et al.
Published: (2013-10-01)

Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor
by: Ling Yang, et al.
Published: (2011-12-01)

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats
by: Ernest Adeghate, et al.
Published: (2021-07-01)

Nociceptin is present in synovial fluid of patients undergoing total knee arthroplasty
by: Thomas A. Verbeek, et al.
Published: (2020-07-01)

Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.
by: D Malfacini, et al.
Published: (2015-01-01)

The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.
by: Zoë L S Brookes, et al.
Published: (2013-01-01)

The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass.
by: Jonathan P Thompson, et al.
Published: (2013-01-01)

Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons
by: Corey Baimel, et al.
Published: (2017-02-01)

A novel bioassay to detect Nociceptin/Orphanin FQ release from single human polymorphonuclear cells.
by: M F Bird, et al.
Published: (2022-01-01)

Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats
by: F. Benvenuti, et al.
Published: (2024-01-01)

Effect of Glucocorticoid Receptor Antagonism on Alcohol Self-Administration in Genetically-Selected Marchigian Sardinian Alcohol-Preferring and Non-Preferring Wistar Rats
by: Federica Benvenuti, et al.
Published: (2021-04-01)

Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers—Possible Treatment Option?
by: Qihui Guan, et al.
Published: (2023-05-01)

Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep
by: Eliana G. Aerts, et al.
Published: (2021-09-01)

Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats
by: Valentina Vozella, et al.
Published: (2021-03-01)

A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications
by: Maria Wołyniak, et al.
Published: (2022-11-01)

Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness
by: Davida Mirra, et al.
Published: (2022-09-01)

In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells.
by: Mark F Bird, et al.
Published: (2022-01-01)

In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells
by: Mark F. Bird, et al.
Published: (2022-01-01)

Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide–Receptor Activation in Rats With Spinal Nerve Injury–Induced Neuropathy
by: Tomoko Takahashi, et al.
Published: (2013-01-01)

Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of Marchigian Sardinian alcohol-preferring (msP) rats
by: Lydia Ojonemile Ayanwuyi, et al.
Published: (2013-04-01)

Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
by: Lucía Gallego-Villarejo, et al.
Published: (2022-01-01)

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
by: Rink-Jan Lohman, et al.
Published: (2023-03-01)

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides
by: Andreas Lieb, et al.
Published: (2021-12-01)

Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder
by: Yong Zhang, et al.
Published: (2019-01-01)

Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
by: Inna eVereshchaka, et al.
Published: (2013-12-01)

Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System
by: Claire Leconte, et al.
Published: (2022-04-01)

Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats
by: Sophia Khom, et al.
Published: (2023-07-01)

Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression
by: Meng-Jing Zhao, et al.
Published: (2021-02-01)