Physical Forces in Glioblastoma Migration: A Systematic Review
The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/7/4055 |
| _version_ | 1797438902676488192 |
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| author | Audrey Grossen Kyle Smith Nangorgo Coulibaly Benjamin Arbuckle Alexander Evans Stefan Wilhelm Kenneth Jones Ian Dunn Rheal Towner Dee Wu Young-Tae Kim James Battiste |
| author_facet | Audrey Grossen Kyle Smith Nangorgo Coulibaly Benjamin Arbuckle Alexander Evans Stefan Wilhelm Kenneth Jones Ian Dunn Rheal Towner Dee Wu Young-Tae Kim James Battiste |
| author_sort | Audrey Grossen |
| collection | DOAJ |
| description | The invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM. |
| first_indexed | 2024-03-09T11:45:01Z |
| format | Article |
| id | doaj.art-f9c3b8eb96374ecb9a626bac12ac3175 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:45:01Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f9c3b8eb96374ecb9a626bac12ac31752023-11-30T23:26:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01237405510.3390/ijms23074055Physical Forces in Glioblastoma Migration: A Systematic ReviewAudrey Grossen0Kyle Smith1Nangorgo Coulibaly2Benjamin Arbuckle3Alexander Evans4Stefan Wilhelm5Kenneth Jones6Ian Dunn7Rheal Towner8Dee Wu9Young-Tae Kim10James Battiste11Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USADepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAThe invasive capabilities of glioblastoma (GBM) define the cancer’s aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. Current forces being studied include properties of the extracellular matrix (ECM), such as stiffness and “sensing” capabilities. There is currently limited data on the physical forces in GBM—both relating to how they influence their environment and how their environment influences them. This review outlines the advances that have been made in the field. It is our hope that further investigation of the physical forces involved in GBM will highlight new therapeutic options and increase patient survival. A search of the PubMed database was conducted through to 23 March 2022 with the following search terms: (glioblastoma) AND (physical forces OR pressure OR shear forces OR compression OR tension OR torsion) AND (migration OR invasion). Our review yielded 11 external/applied/mechanical forces and 2 tumor microenvironment (TME) forces that affect the ability of GBM to locally migrate and invade. Both external forces and forces within the tumor microenvironment have been implicated in GBM migration, invasion, and treatment resistance. We endorse further research in this area to target the physical forces affecting the migration and invasion of GBM.https://www.mdpi.com/1422-0067/23/7/4055glioblastomachemoresistancephysical forcestumor microenvironment |
| spellingShingle | Audrey Grossen Kyle Smith Nangorgo Coulibaly Benjamin Arbuckle Alexander Evans Stefan Wilhelm Kenneth Jones Ian Dunn Rheal Towner Dee Wu Young-Tae Kim James Battiste Physical Forces in Glioblastoma Migration: A Systematic Review International Journal of Molecular Sciences glioblastoma chemoresistance physical forces tumor microenvironment |
| title | Physical Forces in Glioblastoma Migration: A Systematic Review |
| title_full | Physical Forces in Glioblastoma Migration: A Systematic Review |
| title_fullStr | Physical Forces in Glioblastoma Migration: A Systematic Review |
| title_full_unstemmed | Physical Forces in Glioblastoma Migration: A Systematic Review |
| title_short | Physical Forces in Glioblastoma Migration: A Systematic Review |
| title_sort | physical forces in glioblastoma migration a systematic review |
| topic | glioblastoma chemoresistance physical forces tumor microenvironment |
| url | https://www.mdpi.com/1422-0067/23/7/4055 |
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