SPEN is required for Xist upregulation during initiation of X chromosome inactivation
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
Bibliographic Details
| Main Authors: |
Teresa Robert-Finestra,
Beatrice F. Tan,
Hegias Mira-Bontenbal,
Erika Timmers,
Cristina Gontan,
Sarra Merzouk,
Benedetto Daniele Giaimo,
François Dossin,
Wilfred F. J. van IJcken,
John W. M. Martens,
Tilman Borggrefe,
Edith Heard,
Joost Gribnau |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27294-5
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