Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis
Interleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlat...
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-10-01
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100425&tlng=en |
| _version_ | 1811329245560963072 |
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| author | Jianwen Ding Shujun Su Tao You Tingting Xia Xiaoying Lin Zhaocong Chen Liqun Zhang |
| author_facet | Jianwen Ding Shujun Su Tao You Tingting Xia Xiaoying Lin Zhaocong Chen Liqun Zhang |
| author_sort | Jianwen Ding |
| collection | DOAJ |
| description | Interleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlation between the serum IL-6 levels and SLE activity. The PubMed and EMBASE databases were thoroughly searched for relevant studies up to September 2019. Standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to describe the differences between serum IL-6 levels in SLE patients and healthy controls and between those in active SLE patients and inactive SLE patients. The correlation between the serum IL-6 levels and disease activity was evaluated using Fisher’s z values. A total of 24 studies involving 1817 SLE patients and 874 healthy controls were included in this meta-analysis. Serum IL-6 levels were significantly higher in SLE patients than in the healthy controls (pooled SMD: 2.12, 95% CI: 1.21-3.03, Active SLE patients had higher serum IL-6 levels than inactive SLE patients (pooled SMD: 2.12, 95% CI: 1.21-3.03). Furthermore, the pooled Fisher’s z values (pooled Fisher’s z=0.36, 95% CI: 0.26-0.46, p<0.01) showed that there was a positive correlation between the serum IL-6 levels and SLE activity. This study suggested that serum IL-6 levels were higher in patients with SLE than in healthy controls, and they were positively correlated with disease activity when Systemic Lupus Erythematosus Disease Activity Index>4 was defined as active SLE. More homogeneous studies with large sample sizes are warranted to confirm our findings due to several limitations in our meta-analysis. |
| first_indexed | 2024-04-13T15:40:24Z |
| format | Article |
| id | doaj.art-f9c69f03053f4dcaac11f24f4e875bfc |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T15:40:24Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-f9c69f03053f4dcaac11f24f4e875bfc2022-12-22T02:41:10ZengElsevier EspañaClinics1980-53222020-10-017510.6061/clinics/2020/e1801Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysisJianwen Dinghttps://orcid.org/0000-0002-4679-6732Shujun Suhttps://orcid.org/0000-0002-5133-3820Tao Youhttps://orcid.org/0000-0003-3256-7258Tingting Xiahttps://orcid.org/0000-0001-5145-9506Xiaoying Linhttps://orcid.org/0000-0001-9117-5495Zhaocong Chenhttps://orcid.org/0000-0002-0144-2754Liqun Zhanghttps://orcid.org/0000-0003-1452-203XInterleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlation between the serum IL-6 levels and SLE activity. The PubMed and EMBASE databases were thoroughly searched for relevant studies up to September 2019. Standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to describe the differences between serum IL-6 levels in SLE patients and healthy controls and between those in active SLE patients and inactive SLE patients. The correlation between the serum IL-6 levels and disease activity was evaluated using Fisher’s z values. A total of 24 studies involving 1817 SLE patients and 874 healthy controls were included in this meta-analysis. Serum IL-6 levels were significantly higher in SLE patients than in the healthy controls (pooled SMD: 2.12, 95% CI: 1.21-3.03, Active SLE patients had higher serum IL-6 levels than inactive SLE patients (pooled SMD: 2.12, 95% CI: 1.21-3.03). Furthermore, the pooled Fisher’s z values (pooled Fisher’s z=0.36, 95% CI: 0.26-0.46, p<0.01) showed that there was a positive correlation between the serum IL-6 levels and SLE activity. This study suggested that serum IL-6 levels were higher in patients with SLE than in healthy controls, and they were positively correlated with disease activity when Systemic Lupus Erythematosus Disease Activity Index>4 was defined as active SLE. More homogeneous studies with large sample sizes are warranted to confirm our findings due to several limitations in our meta-analysis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100425&tlng=enInterleukin-6Systemic Lupus ErythematosusAutoimmune Disease |
| spellingShingle | Jianwen Ding Shujun Su Tao You Tingting Xia Xiaoying Lin Zhaocong Chen Liqun Zhang Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis Clinics Interleukin-6 Systemic Lupus Erythematosus Autoimmune Disease |
| title | Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis |
| title_full | Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis |
| title_fullStr | Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis |
| title_full_unstemmed | Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis |
| title_short | Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis |
| title_sort | serum interleukin 6 level is correlated with the disease activity of systemic lupus erythematosus a meta analysis |
| topic | Interleukin-6 Systemic Lupus Erythematosus Autoimmune Disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100425&tlng=en |
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