Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art
Abstract Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-02996-6 |
| _version_ | 1797556344349261824 |
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| author | Zahra Hatami Zahra Sadat Hashemi Mohamad Eftekhary Ala Amiri Vahid Karpisheh Kaveh Nasrollahi Reza Jafari |
| author_facet | Zahra Hatami Zahra Sadat Hashemi Mohamad Eftekhary Ala Amiri Vahid Karpisheh Kaveh Nasrollahi Reza Jafari |
| author_sort | Zahra Hatami |
| collection | DOAJ |
| description | Abstract Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail. |
| first_indexed | 2024-03-10T17:01:29Z |
| format | Article |
| id | doaj.art-f9c6e49b4139463d8204e2af7c58400f |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-10T17:01:29Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-f9c6e49b4139463d8204e2af7c58400f2023-11-20T10:59:14ZengBMCCancer Cell International1475-28672023-08-0123111810.1186/s12935-023-02996-6Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics artZahra Hatami0Zahra Sadat Hashemi1Mohamad Eftekhary2Ala Amiri3Vahid Karpisheh4Kaveh Nasrollahi5Reza Jafari6Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares UniversityATMP Department, Breast Cancer Research Center, Motamed Cancer InstituteDepartment of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical SciencesDepartment of Biotechnology, Faculty of Biological Sciences, Alzahra UniversityImmunology Research Center, Tabriz University of Medical SciencesDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares UniversityCellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesAbstract Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail.https://doi.org/10.1186/s12935-023-02996-6Natural killer cellExosomesNK-derived ExosomesCAR-NKCancer immunotherapyFas/FasL pathway |
| spellingShingle | Zahra Hatami Zahra Sadat Hashemi Mohamad Eftekhary Ala Amiri Vahid Karpisheh Kaveh Nasrollahi Reza Jafari Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art Cancer Cell International Natural killer cell Exosomes NK-derived Exosomes CAR-NK Cancer immunotherapy Fas/FasL pathway |
| title | Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art |
| title_full | Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art |
| title_fullStr | Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art |
| title_full_unstemmed | Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art |
| title_short | Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art |
| title_sort | natural killer cell derived exosomes for cancer immunotherapy innovative therapeutics art |
| topic | Natural killer cell Exosomes NK-derived Exosomes CAR-NK Cancer immunotherapy Fas/FasL pathway |
| url | https://doi.org/10.1186/s12935-023-02996-6 |
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