A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis

A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis

Abstract Mild magnetic hyperthermia therapy (MMHT) holds great potential in treating deep‐seated tumors, but its efficacy is impaired by the upregulation of heat shock proteins (HSPs) during the treatment process. Herein, Lac‐FcMOF, a lactose derivative (Lac‐NH2) modified paramagnetic metal‐organic...

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Bibliographic Details
Main Authors: Yi Wang, Zelong Chen, Jiahui Li, Yafei Wen, Jiaxuan Li, Yinghua Lv, Zhichao Pei, Yuxin Pei
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
ferroptosis
heat shock proteins
mild magnetic hyperthermia therapy
paramagnetic metal‐organic framework
redox dyshomeostasis
Online Access:https://doi.org/10.1002/advs.202306178

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