Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition
Abstract Background Acquired hemophilia A (AHA) is a rare acquired bleeding disorder occurred due to the formation of inhibitory antibodies neutralizing endogenous factor VIII. Main body About half the cases are idiopathic. Symptoms include severe and unexpected bleeding that could be life-threateni...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-01-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-021-00074-9 |
| _version_ | 1819349864173010944 |
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| author | Doaa M. El Demerdash Alia Ayad Noha Tawfik |
| author_facet | Doaa M. El Demerdash Alia Ayad Noha Tawfik |
| author_sort | Doaa M. El Demerdash |
| collection | DOAJ |
| description | Abstract Background Acquired hemophilia A (AHA) is a rare acquired bleeding disorder occurred due to the formation of inhibitory antibodies neutralizing endogenous factor VIII. Main body About half the cases are idiopathic. Symptoms include severe and unexpected bleeding that could be life-threatening. High index of suspicion should be raised when unexplained subcutaneous or post-surgical bleeding with isolated prolonged APTT. Conclusions Acquired hemophilia A is a rare underdiagnosed underreported acquired hemostatic disorder that presents with sudden usually life-threatening bleeding; it is crucial to raise awareness and suspicion index of clinicians for early diagnosis and treatment to avoid morbidity and mortality. |
| first_indexed | 2024-12-24T19:07:18Z |
| format | Article |
| id | doaj.art-f9ccae73944c4361ab668635293388e7 |
| institution | Directory Open Access Journal |
| issn | 1110-7782 2090-9098 |
| language | English |
| last_indexed | 2024-12-24T19:07:18Z |
| publishDate | 2022-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-f9ccae73944c4361ab668635293388e72022-12-21T16:43:04ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982022-01-013411610.1186/s43162-021-00074-9Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical conditionDoaa M. El Demerdash0Alia Ayad1Noha Tawfik2Internal Medicine Department, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo UniversityInternal Medicine Department, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo UniversityInternal Medicine Department, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo UniversityAbstract Background Acquired hemophilia A (AHA) is a rare acquired bleeding disorder occurred due to the formation of inhibitory antibodies neutralizing endogenous factor VIII. Main body About half the cases are idiopathic. Symptoms include severe and unexpected bleeding that could be life-threatening. High index of suspicion should be raised when unexplained subcutaneous or post-surgical bleeding with isolated prolonged APTT. Conclusions Acquired hemophilia A is a rare underdiagnosed underreported acquired hemostatic disorder that presents with sudden usually life-threatening bleeding; it is crucial to raise awareness and suspicion index of clinicians for early diagnosis and treatment to avoid morbidity and mortality.https://doi.org/10.1186/s43162-021-00074-9HemophiliaAcquiredBleedingProlonged APTT |
| spellingShingle | Doaa M. El Demerdash Alia Ayad Noha Tawfik Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition The Egyptian Journal of Internal Medicine Hemophilia Acquired Bleeding Prolonged APTT |
| title | Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition |
| title_full | Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition |
| title_fullStr | Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition |
| title_full_unstemmed | Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition |
| title_short | Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition |
| title_sort | acquired hemophilia a aha underreported underdiagnosed undertreated medical condition |
| topic | Hemophilia Acquired Bleeding Prolonged APTT |
| url | https://doi.org/10.1186/s43162-021-00074-9 |
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