Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin
For the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assum...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=2;spage=220;epage=222;aulast= |
| _version_ | 1818992800107069440 |
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| author | Lidiia N Prakhova Aleksandr G Ilves Svetlana N Kizhlo Zhanna I Savintseva |
| author_facet | Lidiia N Prakhova Aleksandr G Ilves Svetlana N Kizhlo Zhanna I Savintseva |
| author_sort | Lidiia N Prakhova |
| collection | DOAJ |
| description | For the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assumed that the disease can be related to both, the direct neurotoxic impact of the HIV and HIV-induced activation of immunopathological processes in the central nervous system (CNS). Reviewed in this paper is a case where the VM presentation deteriorated drastically when treated with highly active antiretroviral therapy, and almost completely regressed after the patient received the intravenous immunoglobulin (IVIg) treatment. The considered case demonstrates the viability of IVIg treatment in patients with HIV-associated CNS pathology, particularly when autoimmune reactions are suspected. The results of placebo-controlled studies of IVIg in patients with HIV-associated myelopathy may give a reliable evaluation of IVIg use in this context. |
| first_indexed | 2024-12-20T20:31:55Z |
| format | Article |
| id | doaj.art-f9ccb96c0558458eabd36c50096e9c8a |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-20T20:31:55Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-f9ccb96c0558458eabd36c50096e9c8a2022-12-21T19:27:20ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492020-01-0123222022210.4103/aian.AIAN_255_18Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulinLidiia N PrakhovaAleksandr G IlvesSvetlana N KizhloZhanna I SavintsevaFor the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assumed that the disease can be related to both, the direct neurotoxic impact of the HIV and HIV-induced activation of immunopathological processes in the central nervous system (CNS). Reviewed in this paper is a case where the VM presentation deteriorated drastically when treated with highly active antiretroviral therapy, and almost completely regressed after the patient received the intravenous immunoglobulin (IVIg) treatment. The considered case demonstrates the viability of IVIg treatment in patients with HIV-associated CNS pathology, particularly when autoimmune reactions are suspected. The results of placebo-controlled studies of IVIg in patients with HIV-associated myelopathy may give a reliable evaluation of IVIg use in this context.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=2;spage=220;epage=222;aulast=human immunodeficiency virus-associated lesions of the nervous systemhuman immunodeficiency virus-associated myelopathyintravenous immunoglobulin administration |
| spellingShingle | Lidiia N Prakhova Aleksandr G Ilves Svetlana N Kizhlo Zhanna I Savintseva Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin Annals of Indian Academy of Neurology human immunodeficiency virus-associated lesions of the nervous system human immunodeficiency virus-associated myelopathy intravenous immunoglobulin administration |
| title | Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin |
| title_full | Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin |
| title_fullStr | Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin |
| title_full_unstemmed | Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin |
| title_short | Successful treatment of human immunodeficiency virus-associated highly active antiretroviral therapy-resistant vacuolar myelopathy with intravenous immunoglobulin |
| title_sort | successful treatment of human immunodeficiency virus associated highly active antiretroviral therapy resistant vacuolar myelopathy with intravenous immunoglobulin |
| topic | human immunodeficiency virus-associated lesions of the nervous system human immunodeficiency virus-associated myelopathy intravenous immunoglobulin administration |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=2;spage=220;epage=222;aulast= |
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