Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications
On the growing clinical demands, superparamagnetic iron oxide nanoparticles (SPIONs) have a vital role due to their infinite physical and chemical properties at the nanoscale. The researchers have started to focus more on the magnetite nanoparticle applications with unique shape and size in various...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-09-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v14i3.p201-207 |
| _version_ | 1827092113841455104 |
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| author | Sivaranjani Sivalingam Mahalakshmi Santhanakrishnan Vijaya Parthasarathy |
| author_facet | Sivaranjani Sivalingam Mahalakshmi Santhanakrishnan Vijaya Parthasarathy |
| author_sort | Sivaranjani Sivalingam |
| collection | DOAJ |
| description | On the growing clinical demands, superparamagnetic iron oxide nanoparticles (SPIONs) have a vital role due to their infinite physical and chemical properties at the nanoscale. The researchers have started to focus more on the magnetite nanoparticle applications with unique shape and size in various filed such as biomedicine, food and environment to synthesize Fe3O4 NP. Here we synthesized SPIONs-Fe3O4 NP successfully by co-precipitation technique. The prepared nanoparticles were characterized using suitable analytical tools for structural, morphological, elemental, optical and thermogravimetric analysis. Moreover, the genotoxicity and hemolysis assay test has been carried out to estimate the toxicity of SPIONs-Fe3O4 NP at various concentrations. The results found that 25 μg/mL concentration of SPIONs-Fe3O4 NP shows good hemocompatibility than other concentrations. The genotoxicity assay was examined in Allium cepa (onion root tips) for chromosomal aberration. Hence, the present study discusses the synthesis characterization, assessing the genotoxicity and hemocompatibility potential for the synthesized Fe3O4 NPs. |
| first_indexed | 2024-03-11T21:44:11Z |
| format | Article |
| id | doaj.art-f9cde880656c4c26b6cd71f59b5db536 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2025-03-20T06:07:02Z |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-f9cde880656c4c26b6cd71f59b5db5362024-10-02T20:26:19ZengTsinghua University PressNano Biomedicine and Engineering2150-55782022-09-0114320120710.5101/nbe.v14i3.p201-207Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical ApplicationsSivaranjani Sivalingam0Mahalakshmi Santhanakrishnan1Vijaya Parthasarathy2Department of Nanoscience and Technology, Bharathiar University, Coimbatore, IndiaDepartment of Nanoscience and Technology, Bharathiar University, Coimbatore, IndiaDepartment of Nanoscience and Technology, Bharathiar University, Coimbatore, IndiaOn the growing clinical demands, superparamagnetic iron oxide nanoparticles (SPIONs) have a vital role due to their infinite physical and chemical properties at the nanoscale. The researchers have started to focus more on the magnetite nanoparticle applications with unique shape and size in various filed such as biomedicine, food and environment to synthesize Fe3O4 NP. Here we synthesized SPIONs-Fe3O4 NP successfully by co-precipitation technique. The prepared nanoparticles were characterized using suitable analytical tools for structural, morphological, elemental, optical and thermogravimetric analysis. Moreover, the genotoxicity and hemolysis assay test has been carried out to estimate the toxicity of SPIONs-Fe3O4 NP at various concentrations. The results found that 25 μg/mL concentration of SPIONs-Fe3O4 NP shows good hemocompatibility than other concentrations. The genotoxicity assay was examined in Allium cepa (onion root tips) for chromosomal aberration. Hence, the present study discusses the synthesis characterization, assessing the genotoxicity and hemocompatibility potential for the synthesized Fe3O4 NPs.https://www.sciopen.com/article/10.5101/nbe.v14i3.p201-207superparamagnetic iron oxide nanoparticles (spions)co-precipitation methodallium cepa testhemolysis assay |
| spellingShingle | Sivaranjani Sivalingam Mahalakshmi Santhanakrishnan Vijaya Parthasarathy Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Nano Biomedicine and Engineering superparamagnetic iron oxide nanoparticles (spions) co-precipitation method allium cepa test hemolysis assay |
| title | Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications |
| title_full | Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications |
| title_fullStr | Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications |
| title_full_unstemmed | Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications |
| title_short | Synthesis, Characterization and In-Vitro Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications |
| title_sort | synthesis characterization and in vitro toxicity assessment of superparamagnetic iron oxide nanoparticles for biomedical applications |
| topic | superparamagnetic iron oxide nanoparticles (spions) co-precipitation method allium cepa test hemolysis assay |
| url | https://www.sciopen.com/article/10.5101/nbe.v14i3.p201-207 |
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