Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection agai...

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Bibliographic Details
Main Authors: Andrew S Bell, James E Mills, Gareth P Williams, James A Brannigan, Anthony J Wilkinson, Tanya Parkinson, Robin J Leatherbarrow, Edward W Tate, Anthony A Holder, Deborah F Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3335879?pdf=render

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