Interleukin-18 and IL-18BP in inflammatory dermatological diseases
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity,...
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.955369/full |
| _version_ | 1828061717932802048 |
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| author | Xiaoyun Wang Xiaoyun Wang Lian Wang Xiang Wen Lu Zhang Xian Jiang Xian Jiang Gu He Gu He |
| author_facet | Xiaoyun Wang Xiaoyun Wang Lian Wang Xiang Wen Lu Zhang Xian Jiang Xian Jiang Gu He Gu He |
| author_sort | Xiaoyun Wang |
| collection | DOAJ |
| description | Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target. |
| first_indexed | 2024-04-10T22:18:09Z |
| format | Article |
| id | doaj.art-f9ce7f1c1cff41919a842ff48b31ff83 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T22:18:09Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f9ce7f1c1cff41919a842ff48b31ff832023-01-18T07:04:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.955369955369Interleukin-18 and IL-18BP in inflammatory dermatological diseasesXiaoyun Wang0Xiaoyun Wang1Lian Wang2Xiang Wen3Lu Zhang4Xian Jiang5Xian Jiang6Gu He7Gu He8Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaInterleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target.https://www.frontiersin.org/articles/10.3389/fimmu.2023.955369/fullIL-18 binding proteinIL-18psoriasisatopic dermatitisrosaceabullous pemphigoid |
| spellingShingle | Xiaoyun Wang Xiaoyun Wang Lian Wang Xiang Wen Lu Zhang Xian Jiang Xian Jiang Gu He Gu He Interleukin-18 and IL-18BP in inflammatory dermatological diseases Frontiers in Immunology IL-18 binding protein IL-18 psoriasis atopic dermatitis rosacea bullous pemphigoid |
| title | Interleukin-18 and IL-18BP in inflammatory dermatological diseases |
| title_full | Interleukin-18 and IL-18BP in inflammatory dermatological diseases |
| title_fullStr | Interleukin-18 and IL-18BP in inflammatory dermatological diseases |
| title_full_unstemmed | Interleukin-18 and IL-18BP in inflammatory dermatological diseases |
| title_short | Interleukin-18 and IL-18BP in inflammatory dermatological diseases |
| title_sort | interleukin 18 and il 18bp in inflammatory dermatological diseases |
| topic | IL-18 binding protein IL-18 psoriasis atopic dermatitis rosacea bullous pemphigoid |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.955369/full |
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