A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017
Abstract Human metapneumovirus (hMPV) can cause severe acute respiratory infection (ARI). We aimed to clarify the clinical and molecular epidemiological features of hMPV. We conducted an ARI surveillance targeting hospitalized children aged 1 month to 14 years in Nha Trang, Vietnam. Nasopharyngeal s...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42692-z |
| _version_ | 1797453381091983360 |
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| author | Hirono Otomaru Hien Anh Thi Nguyen Hien Minh Vo Michiko Toizumi Minh Nhat Le Katsumi Mizuta Hiroyuki Moriuchi Minh Xuan Bui Duc Anh Dang Lay-Myint Yoshida |
| author_facet | Hirono Otomaru Hien Anh Thi Nguyen Hien Minh Vo Michiko Toizumi Minh Nhat Le Katsumi Mizuta Hiroyuki Moriuchi Minh Xuan Bui Duc Anh Dang Lay-Myint Yoshida |
| author_sort | Hirono Otomaru |
| collection | DOAJ |
| description | Abstract Human metapneumovirus (hMPV) can cause severe acute respiratory infection (ARI). We aimed to clarify the clinical and molecular epidemiological features of hMPV. We conducted an ARI surveillance targeting hospitalized children aged 1 month to 14 years in Nha Trang, Vietnam. Nasopharyngeal swabs were tested for respiratory viruses with PCR. We described the clinical characteristics of hMPV patients in comparison with those with respiratory syncytial virus (RSV) and those with neither RSV nor hMPV, and among different hMPV genotypes. Among 8822 patients, 278 (3.2%) were hMPV positive, with a median age of 21.0 months (interquartile range: 12.7–32.5). Among single virus-positive patients, hMPV cases were older than patients with RSV (p < 0.001) and without RSV (p = 0.003). The proportions of clinical pneumonia and wheezing in hMPV patients resembled those in RSV patients but were higher than in non-RSV non-hMPV patients. Seventy percent (n = 195) were genotyped (A2b: n = 40, 20.5%; A2c: n = 99, 50.8%; B1: n = 37, 19%; and B2: n = 19, 9.7%). The wheezing frequency was higher in A2b patients (76.7%) than in those with other genotypes (p = 0.033). In conclusion, we found a moderate variation in clinical features among hMPV patients with various genotypes. No seasonality was observed, and the multiple genotype co-circulation was evident. |
| first_indexed | 2024-03-09T15:22:00Z |
| format | Article |
| id | doaj.art-f9d0252c0d1e45a8bd586f34926c53e1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:22:00Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f9d0252c0d1e45a8bd586f34926c53e12023-11-26T12:47:55ZengNature PortfolioScientific Reports2045-23222023-09-0113111210.1038/s41598-023-42692-zA decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017Hirono Otomaru0Hien Anh Thi Nguyen1Hien Minh Vo2Michiko Toizumi3Minh Nhat Le4Katsumi Mizuta5Hiroyuki Moriuchi6Minh Xuan Bui7Duc Anh Dang8Lay-Myint Yoshida9Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki UniversityDepartment of Bacteriology, National Institute of Hygiene and EpidemiologyDepartment of Pediatrics, Khanh Hoa General HospitalDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki UniversityAntimicrobial Resistance Research Centre, National Institute of Infectious Disease (NIID)Yamagata Prefectural Institute of Public HealthDepartment of Pediatrics, Nagasaki University Graduate School of Biomedical SciencesKhanh Hoa Health Service DepartmentNational Institute of Hygiene and EpidemiologyDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki UniversityAbstract Human metapneumovirus (hMPV) can cause severe acute respiratory infection (ARI). We aimed to clarify the clinical and molecular epidemiological features of hMPV. We conducted an ARI surveillance targeting hospitalized children aged 1 month to 14 years in Nha Trang, Vietnam. Nasopharyngeal swabs were tested for respiratory viruses with PCR. We described the clinical characteristics of hMPV patients in comparison with those with respiratory syncytial virus (RSV) and those with neither RSV nor hMPV, and among different hMPV genotypes. Among 8822 patients, 278 (3.2%) were hMPV positive, with a median age of 21.0 months (interquartile range: 12.7–32.5). Among single virus-positive patients, hMPV cases were older than patients with RSV (p < 0.001) and without RSV (p = 0.003). The proportions of clinical pneumonia and wheezing in hMPV patients resembled those in RSV patients but were higher than in non-RSV non-hMPV patients. Seventy percent (n = 195) were genotyped (A2b: n = 40, 20.5%; A2c: n = 99, 50.8%; B1: n = 37, 19%; and B2: n = 19, 9.7%). The wheezing frequency was higher in A2b patients (76.7%) than in those with other genotypes (p = 0.033). In conclusion, we found a moderate variation in clinical features among hMPV patients with various genotypes. No seasonality was observed, and the multiple genotype co-circulation was evident.https://doi.org/10.1038/s41598-023-42692-z |
| spellingShingle | Hirono Otomaru Hien Anh Thi Nguyen Hien Minh Vo Michiko Toizumi Minh Nhat Le Katsumi Mizuta Hiroyuki Moriuchi Minh Xuan Bui Duc Anh Dang Lay-Myint Yoshida A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 Scientific Reports |
| title | A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 |
| title_full | A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 |
| title_fullStr | A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 |
| title_full_unstemmed | A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 |
| title_short | A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017 |
| title_sort | decade of human metapneumovirus in hospitalized children with acute respiratory infection molecular epidemiology in central vietnam 2007 2017 |
| url | https://doi.org/10.1038/s41598-023-42692-z |
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