Krüppel-like factors in tumors: Key regulators and therapeutic avenues
Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1080720/full |
| _version_ | 1828054650203406336 |
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| author | Yuchen Zhang Chongjie Yao Chongjie Yao Ziyong Ju Danli Jiao Dan Hu Li Qi Shimin Liu Shimin Liu Xueqing Wu Chen Zhao |
| author_facet | Yuchen Zhang Chongjie Yao Chongjie Yao Ziyong Ju Danli Jiao Dan Hu Li Qi Shimin Liu Shimin Liu Xueqing Wu Chen Zhao |
| author_sort | Yuchen Zhang |
| collection | DOAJ |
| description | Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research. |
| first_indexed | 2024-04-10T20:27:00Z |
| format | Article |
| id | doaj.art-f9d7dbf053a544f3a2e786d553252e5f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T20:27:00Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f9d7dbf053a544f3a2e786d553252e5f2023-01-25T10:38:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011310.3389/fonc.2023.10807201080720Krüppel-like factors in tumors: Key regulators and therapeutic avenuesYuchen Zhang0Chongjie Yao1Chongjie Yao2Ziyong Ju3Danli Jiao4Dan Hu5Li Qi6Shimin Liu7Shimin Liu8Xueqing Wu9Chen Zhao10School of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKrüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research.https://www.frontiersin.org/articles/10.3389/fonc.2023.1080720/fullKrüppel-like factortumorsignal transductionmolecular targettumor microenvironment |
| spellingShingle | Yuchen Zhang Chongjie Yao Chongjie Yao Ziyong Ju Danli Jiao Dan Hu Li Qi Shimin Liu Shimin Liu Xueqing Wu Chen Zhao Krüppel-like factors in tumors: Key regulators and therapeutic avenues Frontiers in Oncology Krüppel-like factor tumor signal transduction molecular target tumor microenvironment |
| title | Krüppel-like factors in tumors: Key regulators and therapeutic avenues |
| title_full | Krüppel-like factors in tumors: Key regulators and therapeutic avenues |
| title_fullStr | Krüppel-like factors in tumors: Key regulators and therapeutic avenues |
| title_full_unstemmed | Krüppel-like factors in tumors: Key regulators and therapeutic avenues |
| title_short | Krüppel-like factors in tumors: Key regulators and therapeutic avenues |
| title_sort | kruppel like factors in tumors key regulators and therapeutic avenues |
| topic | Krüppel-like factor tumor signal transduction molecular target tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1080720/full |
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