Widespread nociceptive maps in the human neonatal somatosensory cortex
Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganise...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/71655 |
| _version_ | 1811252284289449984 |
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| author | Laura Jones Madeleine Verriotis Robert J Cooper Maria Pureza Laudiano-Dray Mohammed Rupawala Judith Meek Lorenzo Fabrizi Maria Fitzgerald |
| author_facet | Laura Jones Madeleine Verriotis Robert J Cooper Maria Pureza Laudiano-Dray Mohammed Rupawala Judith Meek Lorenzo Fabrizi Maria Fitzgerald |
| author_sort | Laura Jones |
| collection | DOAJ |
| description | Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n = 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ[HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour. |
| first_indexed | 2024-04-12T16:32:29Z |
| format | Article |
| id | doaj.art-f9d7f958a18c4419b7a7e09d5ffaae17 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:32:29Z |
| publishDate | 2022-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f9d7f958a18c4419b7a7e09d5ffaae172022-12-22T03:25:06ZengeLife Sciences Publications LtdeLife2050-084X2022-04-011110.7554/eLife.71655Widespread nociceptive maps in the human neonatal somatosensory cortexLaura Jones0https://orcid.org/0000-0001-5755-4977Madeleine Verriotis1https://orcid.org/0000-0003-3019-0370Robert J Cooper2Maria Pureza Laudiano-Dray3Mohammed Rupawala4Judith Meek5Lorenzo Fabrizi6https://orcid.org/0000-0002-9582-0727Maria Fitzgerald7https://orcid.org/0000-0003-4188-0123Department of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomDepartment of Developmental Neuroscience, University College London, London, United KingdomDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomElizabeth Garrett Anderson Obstetric Wing, University College London Hospitals, London, United KingdomDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United KingdomTopographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n = 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ[HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour.https://elifesciences.org/articles/71655infantpainbrainsomatotopytopographydevelopment |
| spellingShingle | Laura Jones Madeleine Verriotis Robert J Cooper Maria Pureza Laudiano-Dray Mohammed Rupawala Judith Meek Lorenzo Fabrizi Maria Fitzgerald Widespread nociceptive maps in the human neonatal somatosensory cortex eLife infant pain brain somatotopy topography development |
| title | Widespread nociceptive maps in the human neonatal somatosensory cortex |
| title_full | Widespread nociceptive maps in the human neonatal somatosensory cortex |
| title_fullStr | Widespread nociceptive maps in the human neonatal somatosensory cortex |
| title_full_unstemmed | Widespread nociceptive maps in the human neonatal somatosensory cortex |
| title_short | Widespread nociceptive maps in the human neonatal somatosensory cortex |
| title_sort | widespread nociceptive maps in the human neonatal somatosensory cortex |
| topic | infant pain brain somatotopy topography development |
| url | https://elifesciences.org/articles/71655 |
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