Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review
Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study systematically identified preclinical studies aimed to investigate the possible gut microbiota contribution in neuropathy and neuropathic pain. The systematic review is reported in accordance with PRISMA checklist a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122001656 |
| _version_ | 1818212620427067392 |
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| author | Katia Pane Serena Boccella Francesca Guida Monica Franzese Sabatino Maione Marco Salvatore |
| author_facet | Katia Pane Serena Boccella Francesca Guida Monica Franzese Sabatino Maione Marco Salvatore |
| author_sort | Katia Pane |
| collection | DOAJ |
| description | Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study systematically identified preclinical studies aimed to investigate the possible gut microbiota contribution in neuropathy and neuropathic pain. The systematic review is reported in accordance with PRISMA checklist and guidelines outlined updated to 2020. We included research articles reporting neuropathy-related behavioral evaluations and/or neurological scores coupled to gut microbiota analysis performed by high-throughput technologies in the last ten years. Two investigators performed a search through 3 electronic bibliographic databases for full-text articles (PubMed, Scopus, and EMBASE) and three registries (Prospero, SyRF, and bioRxiv), cross-references, and linear searches. We assessed the methodological quality via the CAMARADES checklist and appraised the heterogeneous body of evidence by narrative synthesis. In total, there were 19 eligible studies. The most of these reports showed significant changes in gut microbiota setting in neuropathy conditions. The major gut microbiome remodeling was through fecal microbiome transplantation. Mechanistic proof of the gut-CNS communication was achieved by measuring inflammatory mediators, metabolic products, or neurotransmitters. As a limitation, we found considerable heterogeneity across eligible studies.We conclude that the current understanding of preclinical findings suggested an association between neuropathy and/or neuropathic pain and gut microbiota modifications. Our analysis provides the basis for further studies targeting microbiota for managing symptoms of neuropathy or other neuroinflammation-based CNS disorders. The systematic review protocol was registered on the international database Prospero under the registration number (257628). |
| first_indexed | 2024-12-12T05:51:17Z |
| format | Article |
| id | doaj.art-f9dab9ec875f45ef93bc262a7c9c70ec |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-12T05:51:17Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-f9dab9ec875f45ef93bc262a7c9c70ec2022-12-22T00:35:41ZengElsevierNeurobiology of Disease1095-953X2022-08-01170105773Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical reviewKatia Pane0Serena Boccella1Francesca Guida2Monica Franzese3Sabatino Maione4Marco Salvatore5IRCCS Synlab SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyDepartment of Experimental Medicine, Pharmacology Division, University of Campania ''L. Vanvitelli'', 80138 Naples, ItalyDepartment of Experimental Medicine, Pharmacology Division, University of Campania ''L. Vanvitelli'', 80138 Naples, Italy; Corresponding authors.IRCCS Synlab SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy; Corresponding authors.Department of Experimental Medicine, Pharmacology Division, University of Campania ''L. Vanvitelli'', 80138 Naples, Italy; IRCSS, Neuromed, Neuropharmacology Division, Pozzilli, ItalyIRCCS Synlab SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyGut microbiota has implications in Central Nervous System (CNS) disorders. Our study systematically identified preclinical studies aimed to investigate the possible gut microbiota contribution in neuropathy and neuropathic pain. The systematic review is reported in accordance with PRISMA checklist and guidelines outlined updated to 2020. We included research articles reporting neuropathy-related behavioral evaluations and/or neurological scores coupled to gut microbiota analysis performed by high-throughput technologies in the last ten years. Two investigators performed a search through 3 electronic bibliographic databases for full-text articles (PubMed, Scopus, and EMBASE) and three registries (Prospero, SyRF, and bioRxiv), cross-references, and linear searches. We assessed the methodological quality via the CAMARADES checklist and appraised the heterogeneous body of evidence by narrative synthesis. In total, there were 19 eligible studies. The most of these reports showed significant changes in gut microbiota setting in neuropathy conditions. The major gut microbiome remodeling was through fecal microbiome transplantation. Mechanistic proof of the gut-CNS communication was achieved by measuring inflammatory mediators, metabolic products, or neurotransmitters. As a limitation, we found considerable heterogeneity across eligible studies.We conclude that the current understanding of preclinical findings suggested an association between neuropathy and/or neuropathic pain and gut microbiota modifications. Our analysis provides the basis for further studies targeting microbiota for managing symptoms of neuropathy or other neuroinflammation-based CNS disorders. The systematic review protocol was registered on the international database Prospero under the registration number (257628).http://www.sciencedirect.com/science/article/pii/S0969996122001656NeuropathyNeuropathic painGut microbiotaBehaviourNeuroinflammationFecal microbiome transplantation |
| spellingShingle | Katia Pane Serena Boccella Francesca Guida Monica Franzese Sabatino Maione Marco Salvatore Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review Neurobiology of Disease Neuropathy Neuropathic pain Gut microbiota Behaviour Neuroinflammation Fecal microbiome transplantation |
| title | Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review |
| title_full | Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review |
| title_fullStr | Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review |
| title_full_unstemmed | Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review |
| title_short | Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review |
| title_sort | role of gut microbiota in neuropathy and neuropathic pain states a systematic preclinical review |
| topic | Neuropathy Neuropathic pain Gut microbiota Behaviour Neuroinflammation Fecal microbiome transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122001656 |
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