Invasive Mole - Case Report of Massive Uterine Destruction
Patient with malignant Gestational Trophoblastic Neoplasm (GTN) was treated by mean of MTX-FA, MAC, EMA-CO and EMA-EP. Changes in serum human chorionic gonadotropine (beta hCG) levels and changes in ultrasonographic findings were checked weekly. Finally transabdominal hysterectomy with ovaries cons...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2008-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2900 |
| _version_ | 1797260858290601984 |
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| author | Branka Nikolić Jelena Lazić Snežana Rakić Svetlana Dragojević-Dikić Aleksandar Ćurković Vesna Lacković |
| author_facet | Branka Nikolić Jelena Lazić Snežana Rakić Svetlana Dragojević-Dikić Aleksandar Ćurković Vesna Lacković |
| author_sort | Branka Nikolić |
| collection | DOAJ |
| description |
Patient with malignant Gestational Trophoblastic Neoplasm (GTN) was treated by mean of MTX-FA, MAC, EMA-CO and EMA-EP. Changes in serum human chorionic gonadotropine (beta hCG) levels and changes in ultrasonographic findings were checked weekly. Finally transabdominal hysterectomy with ovaries conservation was done and polychemotherapy administrated after the operation until three consecutive serum chorionic gonadotropine values were negative. This is a case report of Invasive mole in 32 years old patient without possibility to preserve reproductive health. GTN developed two months after spontaneous abortion in 13th week gestation. No changes in uterine structure were found during the first ultrasonographic examination. Three months after abortion and one month after GTN confirmed, massive destruction of lateral uterine wall was detected during transvaginal Doppler ultrasound examination. Resistance index of 0,366 was significantly lower than normal, with hypervascularisation in affected tissue. Serum beta hCG confirmed poor effect of polychemotherapy treatment and decision for operative treatment was made. Hystological findings after the operation confirmed malignant GTN- invasive mole. Specific changes in ultrasonographic picture could have an impact in therapy making decision and could not be refereed without the most relevant parameter such is serum human chorionic gonadotropine.
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| first_indexed | 2024-04-24T23:32:00Z |
| format | Article |
| id | doaj.art-f9dc4a29667b46399ed36e3bbe37c03e |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:32:00Z |
| publishDate | 2008-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-f9dc4a29667b46399ed36e3bbe37c03e2024-03-15T14:36:52ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2008-11-018410.17305/bjbms.2008.2900540Invasive Mole - Case Report of Massive Uterine DestructionBranka Nikolić0Jelena Lazić1Snežana Rakić2Svetlana Dragojević-Dikić3Aleksandar Ćurković4Vesna Lacković5Obstetrics and Gyneacology Clinic “Narodni front“, Faculty of Medicine, University of BelgradeObstetrics and Gyneacology Clinic “Narodni front“, Faculty of Medicine, University of BelgradeObstetrics and Gyneacology Clinic “Narodni front“, Faculty of Medicine, University of BelgradeObstetrics and Gyneacology Clinic “Narodni front“, Faculty of Medicine, University of BelgradeObstetrics and Gyneacology Clinic “Narodni front“, Faculty of Medicine, University of BelgradeInstitute for Hystology, Faculty of Medicine, University of Belgrade Patient with malignant Gestational Trophoblastic Neoplasm (GTN) was treated by mean of MTX-FA, MAC, EMA-CO and EMA-EP. Changes in serum human chorionic gonadotropine (beta hCG) levels and changes in ultrasonographic findings were checked weekly. Finally transabdominal hysterectomy with ovaries conservation was done and polychemotherapy administrated after the operation until three consecutive serum chorionic gonadotropine values were negative. This is a case report of Invasive mole in 32 years old patient without possibility to preserve reproductive health. GTN developed two months after spontaneous abortion in 13th week gestation. No changes in uterine structure were found during the first ultrasonographic examination. Three months after abortion and one month after GTN confirmed, massive destruction of lateral uterine wall was detected during transvaginal Doppler ultrasound examination. Resistance index of 0,366 was significantly lower than normal, with hypervascularisation in affected tissue. Serum beta hCG confirmed poor effect of polychemotherapy treatment and decision for operative treatment was made. Hystological findings after the operation confirmed malignant GTN- invasive mole. Specific changes in ultrasonographic picture could have an impact in therapy making decision and could not be refereed without the most relevant parameter such is serum human chorionic gonadotropine. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2900gestational trophoblastic neoplasmhuman chorionic gonadotropineresistance indextransvaginal Doppler ultrasonography |
| spellingShingle | Branka Nikolić Jelena Lazić Snežana Rakić Svetlana Dragojević-Dikić Aleksandar Ćurković Vesna Lacković Invasive Mole - Case Report of Massive Uterine Destruction Biomolecules & Biomedicine gestational trophoblastic neoplasm human chorionic gonadotropine resistance index transvaginal Doppler ultrasonography |
| title | Invasive Mole - Case Report of Massive Uterine Destruction |
| title_full | Invasive Mole - Case Report of Massive Uterine Destruction |
| title_fullStr | Invasive Mole - Case Report of Massive Uterine Destruction |
| title_full_unstemmed | Invasive Mole - Case Report of Massive Uterine Destruction |
| title_short | Invasive Mole - Case Report of Massive Uterine Destruction |
| title_sort | invasive mole case report of massive uterine destruction |
| topic | gestational trophoblastic neoplasm human chorionic gonadotropine resistance index transvaginal Doppler ultrasonography |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2900 |
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